Welcome to the website for

Department of Cardiovascular Biology and Medicine     Division of Molecular Aging and Cell Biology

Niigata University Graduate School of Medical and Dental Sciences, Niigata Japan

2018.October

Ippei Shimizu; Invited presentation, Symposium for "The Fire of Life, Cardiac Energy Metabolism"

in 62nd Annual Scientific Meeting of The Korean Society of Cardiology. Great to attend this session with Prof.Kenneth Walsh, and I would like to thank the organizers indeed!

2018.October

Congrats!

Yohko Yoshida; Kobe International Award

Asian-Pacific Diabetes and Obesity Study Group(APDO)

2018.October

Great Job!

Masayoshi Suda, YIA finalist, The 39th Annual Meeting of Japan Society for the Study of Obesity. 

2018. September

Published

Ikegami R*, Shimizu I*,**, Sato T*, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen N, Scheele C, Soga T, Minamino T**. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic dysfunction in obesity. Cell Rep. 24(11):2827-2837 2018

*Co-first author, **Co-corresponding author

2018. September

Congrats!

Yohko Yoshida, Poster award, The 2nd JCS Council Forum on Basic CardioVascular Research (BCVR)

2018. September

Great presentation!

Yuka Hayashi, Symposium, The 2nd JCS Council Forum on Basic CardioVascular Research (BCVR)

2018.September

Congrats!

Masayoshi Suda; Winner YIA session SYMPHONY2018

2018. August

Published

Furuuchi R*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M,

Minamino T. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health.

PLOS One. 13(8):e0202051, 2018, . *   Co-first author

2018.August

We attended European Society of Cardiology (ESC), Munich, Germany

2018. June

Congrats!

Takashi Yamaguchi, Tobitate! (Leap for Tomorrow) Study Abroad Initiative, MEXT, 2018

2018. June

Great Job!

Takumi Watanabe, Finalist of Student Award Competition, Regional Meeting of Japanese Circulation Society, Kantokoushinetsu Regional Office

2018. May

Congrats!

Takashi Yamaguchi; Yujin Memorial Student Award

2018. April

Congrats!

Masayoshi S; Winner, Young Investigators Award, 22^th Annual Meeting of the Society of Cardiovascular Endocrinology and Metabolism (CVEM) 2018, Miyazaki, Japan

2018.April 3rd

We showed up in a TV program introducing BAT and Beige (NHK).

I would like to thank Mr.Amaya and all members in NHK for giving me this great opportunity!

2018. March

Published

Katsuumi G*, Shimizu I*, Yoshida Y, Minamino T. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med 05 March 2018 https://doi.org/10.3389/fcvm.2018.00018. *Co-first author

2018. February

Congrats!

Takashi Yamaguchi, Student Award, Regional Meeting of Japanese Circulation Society, Kantokoushinetsu Regional Office

2018. January

Congrats!

Yohko Yoshida, Poster award, The 1st JCS Council Forum on Basic CardioVascular Research (BCVR)

2017. December

Young Investigator Award Competition, Medical Student Cardiovascular Biology Conference 2017

Winner: Takumi Watanabe

Award for excellence: Ayami Tsushima

2017. December 

Congrats!

Goro Katsuumi, Winner, YIA competetion, Society of Cerebral-Cardio-Vascular Anti-Aging

Yohko Yoshida, Poster award, Society of Cerebral-Cardio-Vascular Anti-Aging

2017. December 

Published

Yoshida Y*, Shimizu I*,**, Minamino T**. Diabetes and adipocyte dysfunction.

Diabetes and Aging-related Complications, 69-84 (Springer publication). *

*Co-first author, ***Co-corresponding author

Figure (from Diabetes and Aging-related Complications, 69-84)

Figure legend

Elimination of senescent white adipocytes, re-browning of whitened brown adipocytes and beiging would contribute for systemic metabolic health.

2017. December

Published

Ikegami R*,Shimizu I*, Yoshida Y, Minamino T. Metabolomic analysis in heart failure.

Circ J. *Co-first author   (Fig. 1 from this review article is described below)

2017. November

We attended American Heart Association 2017, Anaheim, CA, USA.

2017. November

Shimizu I; Research Grant: SENSHIN Medical Research Foundation

2017.October

Shimizu I, became the member of the project for "Elucidating and Controlling Mechanisms of Aging and Longevity, Japan Agency for Medical Research and Development (AMED)".

I would like to thank Professor. Hideki Katagiri, Tohoku University, and the organizers for giving me this great opportunity!!

2017.October

Congrats!

Yuka Hayashi: Niigata University Young Medical Investigation Award

2017. September

We have closed accepting 2nd grade medical students for oversea exchange program 2018, because candidates reached the fixed number. Thank you very much.

2017.August

Congrats!

Yuka Hayashi: Best Moderated Poster Award,

European Society of Cardiology (ESC), Barcelona, Spain

2017. August

Published

Suda M*, Shimizu I*, Yoshida Y, Minamino T. Peripheral blood mononuclear cells for limb ischemia. Therapeutic Angiogenesis (Springer publication). p25-43, *Co-first author    

2017. August

Shimizu I; Research Grant: JSPS KAKENHI, Grant-in-Aid for Challenging Exploratory Research

2017. August

Shimizu I; Research Grant: Takeda Science Foundation

2017. August

Published

Suda M*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of Dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. *Co-first author PLOS One 2017 Aug 3; 12(8)

2017. July

We have started accepting 2nd grade medical students as final candidates for oversea exchange program 2018. We also started Training of Basic Laboratory Skills. We note here that this recruitment will be terminated as soon as it reaches the fixed number.

2017. July

Congrats!

Aoi Ujiie

2017. July

Thank you Prof. Yannick Allanore (Paris Descartes University) for giving us a great talk!

2017. June

KORUS Symposium 2017, Busan, Korea, June28-29

Ippei Shimizu: Invited presentation

2017. June

Congrats!

Yuka Hayashi. Best Presentation Award. 17^th Scientific Meeting of the Japanese Sciety of Anti-Aging Medicine, Tokyo.

2017. May

KSBMB2017, Busan, Korea, May17-19

Ippei Shimizu: Invited presentation

2017. May

Conference on Translational and Therapeutic Perspectives of Brown Adipose.

Scandic Hotel, Copenhagen, Denmark, May2-4.

Ippei Shimizu: Invited presentation

2017. April

Annual Spring Scientific Conference of the Korean Society of Cardiology, 2017, April 21-22, Gyeongju, Korea. Ippei Shimizu: Invited presentation

2017. March

Published

Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yoshida Y, Tsuchida M, Iwama A, Hayano T and Tohru Minamino. Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. Oncotarget. 2017, March.

2017. March

Young Investigator Award Competition, Medical Student Cardiovascular Biology Conference 2017 Winner: Daichi Naito

Award for excellence: Hina Hisano

Award for excellence: Hironori Furuse

2017. March

Japanese Circulation Society 81th Annual Scientific Meeting 2017

Ippei Shimizu: Symposium1, Symposium2 and Chairman (Heart failure, basic).

Yohko Yoshida: Symposium, Featured Research Session, Japan Heart Foundation research grant.

Yuka Hayashi, Goro Katsuumi, Masayoshi Suda, Hiromi Kayamori, Ayako Nagasawa, Toru Watanabe, Ryutaro Ikegami : Poster presentation.

2016. December

Shimizu I; Research Grant: The Uehara Memorial Foundation

2016. December 

Seminar at Inje University, Korea.

2016. December 

Congrats!

Ryutaro Ikegami, Winner, YIA competetion, Society of Cerebral-Cardio-Vascular Anti-Aging

2016. December 

Congrats!

Ayako Nagasawa, Poster award, Society of Cerebral-Cardio-Vascular Anti-Aging

2016. December

Ippei Shimizu, Jokichi Takamine Memorial Award.

CVEM (The Society of Cardiovascular Endocrinology and Metabolism).

2016. December

Young Investigator Award Competition, Medical Student Cardiovascular Biology Conference 2016

Winner: Suzuki Wataru

Award for excellence: Abe Shun

Award for excellence: Takaoki Yuri

2016. November-December 

Shimizu I; Research Grant: 

Kimura Memorial Heart Foundation

TERUMO FOUNDATION for LIFE SCIENCES and ARTS    

Daiichi Sankyo Foundation of Life Science    

2016. October-November

We attended IVBM at Boston and made 9 poster presentations.

2016. October

Thank you Professor. Jin Han and Hyoung Kyu (Inje University, Korea) for visiting us!

2016. October

Yoshida Y; Research Grant:  Kanae Foundation

Shimizu I; Research Grant: Japan Diabetes Foundation

2016. August-September

European Society of Cardiology 2016, Rome, Italy

2016. August

Published 

Katsuumi G*, Shimizu I*^,**, Yoshida Y, Minamino T**. Inflammation and regeneration. 2016,

Aug36;16. The pathological role of cardio-vascular aging in heart failure. 

*Co-first author, **Co corresponding author

2016. August

Official language has become English at our lab meetings and research meetings.

2016. August

<Congrats!>

Katsuumi G; Poster Award, Premium Hypertension Conference2016, Osaka

2016. July

Ji Li from China joined our lab.

2016. July

Congrats Takeshi! Yujin Memorial Student Award

2016. June

Shimizu I; Research Grant: The Bayer Scholarship for Cardiovascular Research, 2016

2016. June

Published 

Shimizu I*, Minamino T*. Physiological and pathological cardiac hypertrophy.

J Mol Cell Cardiol.  2016 Jun 2;97:245-262

2016. May

2016 Taiwan Society of Cardiology, Annual Scientific Meeting, Session of International Young Investigators Award. 2016, May 15, Taipei International Convention Center, Taiwan.

Ippei Shimizu: Invited presentation

2016. April

Annual Spring Scientific Conference of the Korean Society of Cardiology, 2016, April 15-16, Gyeongju, Korea. Ippei Shimizu: Invited presentation

2016. April

Shimizu I; Grants-in-Aid for Encouragement of Young Scientists (A) -KAKENHI-

Yoshida Y; Grants-in-Aid for Encouragement of Young Scientists (B) -KAKENHI-

Nagasawa A; Grants-in-Aid for Scientific Research (C) -KAKENHI-

2016. April

Ippei Shimizu became the Honorary member of Korean Society of Cardiology.

Here I would like to appreciate the organizers of KSC for giving me this great honor.

2016. March

Japanese Circulation Society 80th Annual Scientific Meeting 2016

Ippei Shimizu: Symposium

Yohko Yoshida: Symposium

Shuang Jiao: Featured Research Session

Yuka Hayashi, Goro Katsuumi, Masayoshi Suda, Hiromi Kayamori : Poster

2016. February

Published 

Shimizu I, Yoshida Y, Minamino T. Hypertens Res  (Nature publishing group) 2016 Feb 18, A role for circadian clock in metabolic disease.  

Scheme showing the role of circadian clock dysfunction in systemic metabolic disorder.

(Hypertens Res 2016 Feb 18)

2016. January

Medical Student Round Table with Dr.Yuichi Shimada

from Massachusetts General Hospital, Cardiology Division, Boston, USA

2015. December

Medical Student Cardiovascular Biology Conference & Young Investigator Award Competition 2015    

<Congrats!>

Rhythm Wada; Winner, Young Investigator Award Competition

Hiroaki Yaginuma; Award for excellence

Kozu Ryosuke; Award for excellence

Daisuke Yamada; Prize for encouragement

Daiki Debun; Prize for encouragement

2015. December

Yoshida Y; Research Grant: The Uehara Memorial Foundation

2015. December

<Congrats!>

Yoshida Y; The best Research Award, 10th Research Meeting on Hypertension and Coronary artery Disease, Research Foundation for Community Medicine. Tokyo, Japan.

2015. December

<Congrats!>

Yoshida Y; Young Investigators Award

32th International Society for Heart Research (ISHR), Japanese Section, Kobe, Japan

2015. December

Published 

Shimizu I, Yoshida Y, Minamino T. Diabetes. 2015 Dec;64(12):3984-6.

Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity.

2015. November

 Shimizu I; Research Grant: SENSHIN Medical Research Foundation, 2015

2015. November

American Heart Association 2015, Orlando, USA

2015. October

Yoshida Y: Research Grant:  Suzuken Memorial Foundation

2015. October

Published

Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I, Miki T, Kobayashi Y, and Minamino T. Aging and Mechanism of Disease. (Nature publishing Group), 2015 October, Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation.

2015. October

<Congrats!>

Jiao S; Niigata University Young Medical Investigation Award    

2015. October

 Shimizu I; Research Grant:  Kanae Foundation

2015. October

 Shimizu I; Research Grant: Grant for Basic Science Research Projects from The Sumitomo Foundation

2015. September

Published

Yoshida Y*, Shimizu I*, Minamino T. Inflammation and regeneration. 2015 September, 

The pathological role of adipose tissue aging in the progression of systemic insulin resistance.

*Co-first author

2015. September

 Shimizu I; Research Grant:  Banyu Foundation Research Grant

2015. August-September

European Society of Cardiology 2015, London

2015. August

Yoshida Y: Research Grant:  Takeda Science Foundation

2015. August-September Osong, Korea.    

Annual Summer Symposium of the Basic Science study group, branch of the Korean Society of Cardiology, 2015, August 21-22, Osong, Korea.    

Ippei Shimizu: Invited presentation

2015. August

<Congrats!>

Suda M; Poster Award, Premium Hypertension Conference2015, Tokyo

2015. July

<Congrats!>

 Yoshida Y; Travel Award for the ESC Congress 2015 in London, UK

2015. July

 Shimizu I; Research Grant:  Tsukada grant for Niigata University Medical Research

2015. June

Published

Yoshida Y*, Shimizu I*, Katsuumi G*, Jiao S, Suda M, Hayashi Y, Minamino T.   * Co-first author

p53-induced inflammation exacerbates cardiac dysfunction during pressure overload.

J Mol Cell Cardiol. 2015 June 6

2015. May Busan and Gwangju, Korea

Inje Uni, Busan, Korea. Korean Diabetes Association. Gwangju, Korea.

2015. May

Published

Shimizu I*, Yoshida Y, Minamino T*.   * Co-corresponding author

Pathological role of adipose tissue dysfunction in cardio-metabolic disorders.

Int Heart J. 2015 May

2015. April

Published

Shimizu I*, Walsh K.   * Corresponding author

The Whitening of Brown Fat and Its Implications for Weight Management in Obesity

Current Obesity Reports. 2015 April

2015. January

 Shimizu I; Research Grant:  Japan Heart Foundation Research Grant

2014. December

Medical Student Cardiovascular Biology Conference 2014 & Young Investigator Award Competition

<Congrats!>

Takeshi Sato: Winner, Young Investigator Award Competetion

2014. December

 Shimizu I; Research Grant: The Uehara Memorial Foundation

2014. December

 Shimizu I; Research Grant:  ONO Medical Research Foundation, 2014

2014. December

Published

Shimizu I, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease.

Cell Metab. 2014 Dec 2;20(6):967-977. 

2014. December

 Shimizu I; Research Grant:  The Senri Life Science Foundation, 2014

2014. November

 Shimizu I; Research Grant:  The Nakajima Foundation, 2015

2014. November

Shimizu I; First Place, Young Investigator Competition of the 58th Annual Scientific Meeting. The Korean Society of Cardiology. Nov 28, 2014, Kintex, Ilsan, Republic of Korea.

2014. November

 Shimizu I; Research Grant:  Kowa Life Science Foundation, 2014

2014. November

 Shimizu I; Research Grant: SENSHIN Medical Research Foundation, 2014

2014. November

<Congrats!>

 Katsuumi G; Winner, Young Investigators Award, 18^th Annual Meeting of the Society of Cardiovascular Endocrinology and Metabolism (CVEM) 2014, Yokohama, Japan

2014. November

<Congrats!>

 Katsuumi G; Travel Award for the 18^th Annual Meeting of the Society of Cardiovascular Endocrinology and Metabolism (CVEM) 2014, Yokohama, Japan

2014. October

 Shimizu I; Dean's Award, Niigata University 2014

2014. October

 Shimizu I; Research Grant: SUZUKEN memorial foundation 2014

2014. October

 Shimizu I; Research Grant: HOKUTO Corporation 2014

2014. September

 Shimizu I; Research Grant: Mochida Memorial Foundation for Medical & Pharmaceutical Research 2014

2014. September

<Congrats!>

 Katsuumi G; Travel Award for the 37^th Annual Scientific Meeting of the Japanese Society of Hypertension 2014, Yokohama, Japan

2014. August

<Congrats!>

 Yoshida Y; Travel Award for the ESC Congress 2014 in Barcelona, Spain

2014. June

Published

Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I, Minamino T. PLOS One. 2014; 9(6). Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway.

2014. April

Published

Shimizu I, Tamar A, Kikuchi R, Shimizu A, Papanicolaou K, Maclauchlan S, Maruyama S,Walsh K.

J Clin Invest. 2014; Apr 4.Vascular rarefaction mediates whitening of brown fat in obesity. 

2014. April

<Hello Everyone!!> 

Division of Molecular Aging and Cell Biology has been founded on April 1st 2014, endowed by Bourbon Corporation Japan, at Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

This is the joint laboratory with Department of Cardiovascular Biology and Medicine (Tohru Minamino; Professor and Chairman).

We will focus on establishing pre-emptive medicine for aging and age-related diseases.