Our mission is to generate new therapies for cardiovascular-metabolic disorders, and reverse unfavorable aspects of aging.

- What's new -

December 2022

Ippei Shimizu; Made an invited talk at Society of Cerebral-Cardio-Vascular Anti-Aging, Japan.

November 2022

Great job Ruby and Yung Ting!

American Heart Association, 2022, Chicago.

Congrats! Ruby for Paul Dudley White International Scholar Award!

October 2022

Ippei Shimizu; Made an invited talk at Diabetes Seminar, Japan.

October 2022

Published

Ryo Furuuchi*, Ippei Shimizu*,**, Yohko Yoshida, Goro Katsuumi, Masayoshi Suda, Yoshiaki Kubota, Kenneth Walsh, Tohru Minamino.

Endothelial SIRT-1 has a critical role for the maintenance of capillarization in brown adipose tissue.

 iScience. 2022 *Co-first author, **corresponding

October 2022

Ippei Shimizu; Made an invited talk at SHVM, Seoul, Korea.

Was my great honor to meet, discuss and share time with legendary researchers.

Thank you Jaetaek for the kind invitation!!

October 2022
Congrats!
Yohko Yoshida

Best Poster Presentation Award, International Society of Hypertension (ISH) 2022 Kyoto

October 2022

Dr.Daria Krokva, Ms.Mayumi Kobayashi joined our lab.

September 2022

Ippei Shimizu; Made an invited talk at Japanese College of Cardiology, Japan.

 

September 2022

Published

Yoshida Y*, Shimizu I*,**, Shimada A, Nakahara K, Yanagisawa S, Kubo M, Fukuda S, Ishii C, Yamamoto H, Ishikawa T, Kano K, Aoki J, Hayashi Y, Ikegami R, Katsuumi G, Suda M, Ozaki K, Kashimura T, Izumi D, Yoshida Y, Okuda S, Ohta S, Okamoto S, Minokoshi Y, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T** and Minamino T**. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Sci Rep. 2022, 12:14883, *Co-first author, **corresponding author

August 2022

Ippei Shimizu; Invited talk at Basic Research Update Web Conference in Kyushu University (online).

Thank you very much Dr.Matsushima for giving me this opportunity

July 2022

Ippei Shimizu; Invited talk at 52nd Annual Scientific Meeting of the Japanese Society for Circulation Research.

July 2022

Ippei Shimizu; Invited talk at Tokushima University (online).

Thank you very much Dr.Aihara for giving me this opportunity!

July 2022

Ippei Shimizu; Invited talk at Japan Atherosclerosis Society.

Thank you very much Dr.Maeda for giving me this opportunity!

July 2022

Ippei Shimizu; Invited talk at Young Researcher Conference in Kyoto University (YRCK).

Thank you very much Dr.Horie for giving me this opportunity!

July 2022

Published

Hayashi Y*, Shimizu I*,**, Yoshida Y*, Ikegami R, Suda M, Katsuumi G, Nakao M, Fujiki S, Abe M, Sakimura K, Okuda S, Hayano T, Walsh K, Jespersen NJ, Nielsen S, Scheele C, Minamino T**. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity. iScience. 2022 *Co-first author, **corresponding

July 2022

Prof. Yasuyuki Fujita, Kyoto University, and Dr. Kenichi Iijima, Juntendo University gave us talks at MARS. Thank you very much!

June 2022

Ippei Shimizu; appointed as ISHR Mid-Career Investigator (MCI) member. Feel honored for having this opportunity.

June 2022

Ippei Shimizu; Grant from Kobayashi Magobei Memorial Medical Promotion Foundation of Japan

May 2022

Prof. Ishitani, Osaka University, and Dr. Yoshida, Juntendo University gave us talks at MARS. Thank you very much!

April 2022

Prof.Masaki Ieda,  University of Tsukuba, gave us a talk at MARS. Thank you very much!

April 2022

Published

Suda M*, Shimizu I*, Katsuumi G*, Yoshida Y, Matsumoto N, Yoshida Y, Katayama A, Wada J, Seki M, Suzuki Y, Okuda S, Ozaki K, Matsui M, Minamino T. Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells. Sci Rep. 2022, April 20, 6522. *Co-first author.

 

April 2022

Published

Yoshida Y*, Shimizu I*, Yung Ting Hsiao*, Hayashi Y, Suda M, Katsuumi G, Ikegami R, Nakao M, Sakai R, Seki M, Suzuki Y, Okuda S, Soga T, Minamino T. Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue. iScience. 2022 *Co-first author

 

April 2022

Published

Yoshida Y*, Shimizu I*,**, Minamino T*. Capillaries as a Therapeutic Target for Heart Failure. 

J Atheroscler Thromb. 2022 Apr 1. doi: 10.5551/jat.RV17064. Online ahead of print. PMID: 35370224

*Joint Senior authors, **corresponding author

April 2022

Ippei Shimizu; Grant from Japan Foundation for Applied Enzymology

March 2022

Ippei Shimizu; Grant from the Japanese Circulation Society

Japanese Circulation Society Grant for Future-Pioneering Doctors for Basic Research

March 2022

Japanese Society of Cardiology. My great honor to chair this session with Prof.Junichi Sadoshima, Rutgers New Jersey, USA.

Thank you very much, Adam, Jeffi, Prof. Jin Han for giving us your great talk!

March 2022

Professor. Shujiro Okuda (Niigata University) and Professor. Katsumi Miyauchi (Juntendo University) gave us talks at MARS.

Thank you very much!

February 2022

Our collaborative research published

Congrats, Nammi, Hyoung Kyu and Prof. Jin Han!!

Park N, Marquez J, Pham T, Ko TH, Youm JB, Kim M, Choi SH, Moon J, Flores J, Ko K, Rhee BD, Shimizu I, Minamino T, Ha JD, Hwang JY, Yang SJ, Park CS, Kim HK and Han J. Cereblon contributes to cardiac dysfunction by degrading Cav1.2α. European Heart Journal. 2022, Feb; 22.

February 2022

Ippei Shimizu; Presented at Cardiovascular & Aging Research Cluster IMERI, Jakarta, Indonesia (online).

Thank you Jeffi for this kind invitation!

February 2022

Ippei Shimizu; Grant from Japan Diabetes Foundation and Novo Nordisk Pharma Ltd.

February 2022

Ippei Shimizu; Selected as MVP at Souhatsu (JST FOREST Program) presentation.

February 2022

Ippei Shimizu; Invited talk at Future of Atherosclerosis , Hypertension and Diabetes Mellitus

January 2022

Ippei Shimizu; The Nakatomi Foundation

January 25th 2022

Dr. Akihito Ishigami (Tokyo Metropolitan Institute of Gerontology) and Dr. Taka Furihata (Juntendo University) gave us a talk at MARS.

Thank you very much!

January 2022

Published

Hsiao Y.T.*, Shimizu I*,**, Yoshida Y, Minamino T**. Role of circulating molecules in age-related cardiovascular and metabolic disorders. Inflammation and regeneration. 42:2, 2022. Co-first author, *corresponding author


December 2021

Ippei Shimizu; Invited talk at Joint Innovative Knowledge Symposium (JIKS) (Korea)

Thank you very much Prof. Jin Han and Hyoung Kyu for this great opportunity!

December 2021, 25th

Ippei Shimizu; Invited talk at Science Pioneers Consortium.

Thank you very much Prof.Mukoyama, and Prof.Yokote and organizers for this great opportunity!

December 2021

Ippei Shimizu; Tokyo Biochemical research Foundation

December 2021 13th

Our lab will undertake joint research with Dr. Akihito Ishigami's lab, Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology.

(https://aging-regulation.jp/index.html)

December 2021 13th

Our lab was introduced in NHK TV show (あさイチ).

December 2021

Published

Suda M*, Shimizu I*, Katsuumi G*, Yoshida Y, Hayashi Y, Ikegami R, Matsumoto N, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Matsui M, Minamino T. (2021) Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nature Aging. Dec 10. *Co-first author

December 2021 7th

Our lab was introduced in Nippon TV show (ザ!世界仰天ニュース).

November 2021 16th

Dr. Tomohisa Nagoshi (Jikei University) , Dr. Masato Iwabu (University of Tokyo) gave us a talk at MARS.

Thank you very much!

November 2021

Ippei Shimizu; SENSHIN Medical Research Foundation

November 2021 11th

Yohko Yoshida, Ippei Shimizu; We will make presentations at 6th ICE on IMERI, Indonesia University.

Thank you for giving us this great opportunities!

November 2021 6th

Ippei Shimizu; Made presentations at 6th ICE on IMERI, Indonesia University. Thank you for giving us this great opportunities!

November 2021

Ippei Shimizu; Presented at Korean Society for Molecular and Cellular Biology. I would like to thank Hyoung Kyu and organizers for giving me this great opportunities.

October 2021

Professor Takashi Sato in Tokyo Medical and Dental University gave us a talk at MARS (Cardiovascular-Metabolism-Aging Research Seminar); ISHR U45-Satellite Symposium. Thank you Dr. Sato!

October 2021

Ippei Shimizu; Presented at Korean Society of Cardiology. I would like to thank Prof. Jin Han and organizers for giving me this great opportunities.

October 2021

Ippei Shimizu; Astellas Award for the Best Biomedical Research

September 2021

Ippei Shimizu; Presented at Global Innovator Summit, National Academy of Medicine, USA. 

September 2021

Published

Nakao M*, Shimizu I*,**, Katsuumi G, Yoshida Y, Suda M, Hayashi Y, Ikegami R, Hsiao Yung Ting, Okuda S, Soga T, Minamino T**.

Empagliflozin Maintains Capillarization and Improves Cardiac Function in a Murine Model of Left Ventricular Pressure Overload.

Sci Rep 11, Article number: 18384 (2021). *Co-first author, **Co-corresponding author

Graphical abstract of our findings.

(Fig. 4J; Sci Rep 11, Article number: 18384 (2021))

 

We found empagliflozin enhances capillarization in heart and ameliorate cardiac dysfunction upon left ventricle pressure overload.

Together with our previous studies in Nature 2007, J Clin Invest 2010, Cell Metab 2012, our studies indicate the critical role of maintaining capillaries in heart.

September 2021

Professor Sakai Mashito in Nippon Medical School gave us a talk at MARS (Cardiovascular-Metabolism-Aging Research Seminar); ISHR U45-Satellite Symposium. Thank you Dr. Sakai!

July 2021 

José Javier Fuster Ortuño in CNIC gave us a talk at CREATE-International Symposium! Thank you Jose!!

(The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Hematovascular Pathophysiology, Madrid, Spain)

July, 2021

Frontiers in Cardiovascular Medicine; IF 6.05! Awesome!!

https://www.frontiersin.org/journals/cardiovascular-medicine/sections/cardiovascular-metabolism#

April, 2021

Ippei Shimizu appointed as a leader of U45-ISHR Japanese section.

(International Society of Heart Research).

https://www.u45ishr.com/

April, 2021

We moved to Juntendo University, Tokyo, Japan.

March, 2021
Congrats!
Winner; Yung Ting Hsiao; YIA competition for International Students, 84th Annual Scientific Meeting of Japanese Circulation Society 2021 (JCS2021)

March 2021

Published
Hsiao
YT*, Shimizu I*,**, Wakasugi T, Jiao S, Watanabe T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Kashimura T, Ozaki K, Hanawa H, Minamino T**. Cardiac Mitofusin-1 is Reduced in Non-responding Patients with Idiopathic Dilated Cardiomyopathy.  Sci Rep. , Mar24; 11(1):6722, 2021. *Co-first author, **Co-corresponding author