Our mission is to generate new therapies for cardiovascular-metabolic disorders, and reverse unfavorable aspects of aging.
- What's new -
Prof.Masaki Ieda, University of Tsukuba, gave us a talk at MARS. Thank you very
Suda M*, Shimizu I*, Katsuumi G*, Yoshida Y, Matsumoto N, Yoshida Y, Katayama A, Wada J, Seki M, Suzuki Y, Okuda S, Ozaki K, Matsui M, Minamino T. Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells. Sci Rep. 2022, April 20, 6522. *Co-first author.
Yoshida Y*, Shimizu I*, Yung Ting Hsiao*, Hayashi Y, Suda M, Katsuumi G, Ikegami R, Nakao M, Sakai R, Seki M, Suzuki Y, Okuda S, Soga T, Minamino T. Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue. iScience. 2022 *Co-first author
Yoshida Y*, Shimizu I*,**, Minamino T*. Capillaries as a Therapeutic Target for Heart Failure.
J Atheroscler Thromb. 2022 Apr 1. doi: 10.5551/jat.RV17064. Online ahead of print. PMID: 35370224
*Joint Senior authors, **corresponding author
Ippei Shimizu; Grant from Japan Foundation for Applied Enzymology
Ippei Shimizu; Grant from the Japanese Circulation Society
Japanese Circulation Society Grant for Future-Pioneering Doctors for Basic Research
Japanese Society of Cardiology. My great honor to chair this session with Prof.Junichi Sadoshima, Rutgers New Jersey, USA.
Thank you very much, Adam, Jeffi, Prof. Jin Han for giving us your great talk!
Professor. Shujiro Okuda (Niigata University) and Professor. Katsumi Miyauchi (Juntendo University) gave us talks at MARS.
Thank you very much!
Our collaborative research published
Contrats, Nammi, Hyoung Kyu and Prof. Jin Han!!
Park N, Marquez J, Pham T, Ko TH, Youm JB, Kim M, Choi SH, Moon J, Flores J, Ko K, Rhee BD, Shimizu I, Minamino T, Ha JD, Hwang JY, Yang SJ, Park CS, Kim HK and Han J. Cereblon contributes to cardiac dysfunction by degrading Cav1.2α. European Heart Journal. 2022, Feb; 22.
Ippei Shimizu; Presented at Cardiovascular & Aging Research Cluster IMERI, Jakarta, Indonesia (online).
Thank you Jeffi for this kind invitation!
Ippei Shimizu; Grant from Japan Diabetes Foundation and Novo Nordisk Pharma Ltd.
Ippei Shimizu; Selected as MVP at Souhatsu (JST FOREST Program) presentation.
Ippei Shimizu; The Nakatomi Foundation
January 25th 2022
Dr. Akihito Ishigami (Tokyo Metropolitan Institute of Gerontology) and Dr. Taka Furihata (Juntendo University) gave us a talk at MARS.
Thank you very much!
Hsiao Y.T.*, Shimizu I*,**, Yoshida Y, Minamino T**. Role of circulating molecules in age-related cardiovascular and metabolic disorders. Inflammation and regeneration. 42:2, 2022. Co-first author, *corresponding author
Ippei Shimizu; Invited talk at Joint Innovative Knowledge Symposium (JIKS) (Korea)
Thank you very much Prof. Jin Han and Hyoung Kyu for this great opportunity!
December 2021, 25th
Ippei Shimizu; Invited talk at Science Pioneers Consortium.
Thank you very much Prof.Mukoyama, and Prof.Yokote and organizers for this great opportunity!
Ippei Shimizu; Tokyo Biochemical research Foundation
December 2021 13th
Our lab will undertake joint research with Dr. Akihito Ishigami's lab, Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology.
December 2021 13th
Our lab was introduced in NHK TV show (あさイチ).
Suda M*, Shimizu I*, Katsuumi G*, Yoshida Y, Hayashi Y, Ikegami R, Matsumoto N, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Matsui M, Minamino T. (2021) Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nature Aging. Dec 10. *Co-first author
December 2021 7th
Our lab was introduced in Nippon TV show (ザ！世界仰天ニュース).
November 2021 16th
Dr. Tomohisa Nagoshi (Jikei University) , Dr. Masato Iwabu (University of Tokyo) gave us a talk at MARS.
Thank you very much!
Ippei Shimizu; SENSHIN Medical Research Foundation
November 2021 11th
Yohko Yoshida, Ippei Shimizu; We will make presentations at 6th ICE on IMERI, Indonesia University.
Thank you for giving us this great opportunities!
November 2021 6th
Ippei Shimizu; Made presentations at 6th ICE on IMERI, Indonesia University. Thank you for giving us this great opportunities!
Ippei Shimizu; Presented at Korean Society for Molecular and Cellular Biology. I would like to thank Hyoung Kyu and organizers for giving me this great opportunities.
Professor Takashi Sato in Tokyo Medical and Dental University gave us a talk at MARS (Cardiovascular-Metabolism-Aging Research Seminar); ISHR U45-Satellite Symposium. Thank you Dr. Sato!
Ippei Shimizu; Presented at Korean Society of Cardiology. I would like to thank Prof. Jin Han and organizers for giving me this great opportunities.
Ippei Shimizu; Astellas Award for the Best Biomedical Research
Ippei Shimizu; Presented at Global Innovator Summit, National Academy of Medicine, USA.
Nakao M*, Shimizu I*,**, Katsuumi G, Yoshida Y, Suda M, Hayashi Y, Ikegami R, Hsiao Yung Ting, Okuda S, Soga T, Minamino T**.
Empagliflozin Maintains Capillarization and Improves Cardiac Function in a Murine Model of Left Ventricular Pressure Overload.
Sci Rep 11, Article number: 18384 (2021). *Co-first author, **Co-corresponding author
Graphical abstract of our findings.
(Fig. 4J; Sci Rep 11, Article number: 18384 (2021))
We found empagliflozin enhances capillarization in heart and ameliorate cardiac dysfunction upon left ventricle pressure overload.
Together with our previous studies in Nature 2007, J Clin Invest 2010, Cell Metab 2012, our studies indicate the critical role of maintaining capillaries in heart.
Professor Sakai Mashito in Nippon Medical School gave us a talk at MARS (Cardiovascular-Metabolism-Aging Research Seminar); ISHR U45-Satellite Symposium. Thank you Dr. Sakai!
José Javier Fuster Ortuño in CNIC gave us a talk at CREATE-International Symposium! Thank you Jose!!
(The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Hematovascular Pathophysiology, Madrid, Spain)
Frontiers in Cardiovascular Medicine; IF 6.05! Awesome!!
Ippei Shimizu appointed as a leader of U45-ISHR Japanese section.
(International Society of Heart Research).
We moved to Juntendo University, Tokyo, Japan.
Winner; Yung Ting Hsiao; YIA competition for International Students, 84th Annual Scientific Meeting of Japanese Circulation Society 2021 (JCS2021)
Hsiao YT*, Shimizu I*,**, Wakasugi T, Jiao S, Watanabe T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Kashimura T, Ozaki K, Hanawa H, Minamino T**. Cardiac Mitofusin-1 is Reduced in Non-responding Patients with Idiopathic Dilated Cardiomyopathy. Sci Rep. , Mar24; 11(1):6722, 2021. *Co-first author, **Co-corresponding author