Our mission is to generate new therapies for cardiovascular-metabolic disorders, and reverse unfavorable aspects of aging.

- What's new -

January 2022

Published

Hsiao Y.T.*, Shimizu I*,**, Yoshida Y, Minamino T**. Role of circulating molecules in age-related cardiovascular and metabolic disorders. Inflammation and regeneration. 42:2, 2022. Co-first author, *corresponding author


December 2021, 25th

Ippei Shimizu; Invited talk at Science Pioneers Consortium.

Thank you very much Prof.Mukoyama, and Prof.Yokote and organizers for this great opportunity!

December 2021

Ippei Shimizu; Tokyo Biochemical research Foundation

December 2021 13th

Our lab will undertake joint research with Dr. Akihito Ishigami's lab, Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology.

(https://aging-regulation.jp/index.html)

December 2021 13th

Our lab was introduced in NHK TV show (あさイチ).

December 2021

Published

Suda M*, Shimizu I*, Katsuumi G*, Yoshida Y, Hayashi Y, Ikegami R, Matsumoto N, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Matsui M, Minamino T. (2021) Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nature Aging. Dec 10. *Co-first author

December 2021 7th

Our lab was introduced in Nippon TV show (ザ!世界仰天ニュース).

November 2021 16th

Dr. Tomohisa Nagoshi (Jikei University) , Dr. Masato Iwabu (University of Tokyo) gave us a talk at MARS.

November 2021

Ippei Shimizu; SENSHIN Medical Research Foundation

November 2021 11th

Yohko Yoshida, Ippei Shimizu; We will make presentations at 6th ICE on IMERI, Indonesia University.

Thank you for giving us this great opportunities!

November 2021 6th

Ippei Shimizu; Made presentations at 6th ICE on IMERI, Indonesia University. Thank you for giving us this great opportunities!

November 2021

Ippei Shimizu; Presented at Korean Society for Molecular and Cellular Biology. I would like to thank Hyoung Kyu and organizers for giving me this great opportunities.

October 2021

Professor Takashi Sato in Tokyo Medical and Dental University gave us a talk at MARS (Cardiovascular-Metabolism-Aging Research Seminar); ISHR U45-Satellite Symposium. Thank you Dr. Sato!

October 2021

Ippei Shimizu; Presented at Korean Society of Cardiology. I would like to thank Prof. Jin Han and organizers for giving me this great opportunities.

October 2021

Ippei Shimizu; Astellas Award for the Best Biomedical Research

September 2021

Ippei Shimizu; Presented at Global Innovator Summit, National Academy of Medicine, USA. 

September 2021

Published

Nakao M*, Shimizu I*,**, Katsuumi G, Yoshida Y, Suda M, Hayashi Y, Ikegami R, Hsiao Yung Ting, Okuda S, Soga T, Minamino T**.

Empagliflozin Maintains Capillarization and Improves Cardiac Function in a Murine Model of Left Ventricular Pressure Overload.

Sci Rep 11, Article number: 18384 (2021). *Co-first author, **Co-corresponding author

Graphical abstract of our findings.

(Fig. 4J; Sci Rep 11, Article number: 18384 (2021))

 

We found empagliflozin enhances capillarization in heart and ameliorate cardiac dysfunction upon left ventricle pressure overload.

Together with our previous studies in Nature 2007, J Clin Invest 2010, Cell Metab 2012, our studies indicate the critical role of maintaining capillaries in heart.

September 2021

Professor Sakai Mashito in Nippon Medical School gave us a talk at MARS (Cardiovascular-Metabolism-Aging Research Seminar); ISHR U45-Satellite Symposium. Thank you Dr. Sakai!

July 2021 

José Javier Fuster Ortuño in CNIC gave us a talk at CREATE-International Symposium! Thank you Jose!!

(The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Hematovascular Pathophysiology, Madrid, Spain)

July, 2021

Frontiers in Cardiovascular Medicine; IF 6.05! Awesome!!

https://www.frontiersin.org/journals/cardiovascular-medicine/sections/cardiovascular-metabolism#

April, 2021

Ippei Shimizu appointed as a leader of U45-ISHR Japanese section.

(International Society of Heart Research).

https://www.u45ishr.com/

April, 2021

We moved to Juntendo University, Tokyo, Japan.

March, 2021
Congrats!
Winner; Yung Ting Hsiao; YIA competition for International Students, 84th Annual Scientific Meeting of Japanese Circulation Society 2021 (JCS2021)

March 2021

Published
Hsiao
YT*, Shimizu I*,**, Wakasugi T, Jiao S, Watanabe T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Kashimura T, Ozaki K, Hanawa H, Minamino T**. Cardiac Mitofusin-1 is Reduced in Non-responding Patients with Idiopathic Dilated Cardiomyopathy.  Sci Rep. , Mar24; 11(1):6722, 2021. *Co-first author, **Co-corresponding author