IPPEI SHIMIZU M.D., Ph.D. FESC. FAHA　

Associate Professor

Department of Cardiovascular Biology and Medicine, 

Division of Molecular Aging and Cell Biology


Research chief of the ischemic heart disease and regenerative therapy group

Research chief of the heart failure group

Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

・Member of the project for "Elucidating and Controlling Mechanisms of Aging and Longevity, Japan Agency for Medical Research and Development (AMED)".

・Associate Editorial board member; Frontiers in Cardiovascular Medicine

・Editorial board member; Scientific Reports, J Mol Cell Cardiol

・Fellow; European Society of Cardiology (FESC)

・Fellow; American Heart Association (FAHA)

ORCID ID; https://orcid.org/0000-0003-3333-8131

Loop profile: 490714

Scopus Author ID: 7202212470

 E-mail:  ippeishimizu[at]yahoo.co.jp / ippeishimizu[at]med.niigata-u.ac.jp

Please replace [at] with @ when contacting us.

QUALIFICATIONS

1.     Board Certified Member of the Japanese Society of Internal Medicine, 2005

2.     Cardiovascular Specialist of Japanese Circulation Society, 2009

3.     Doctor of Philosophy, 2010

4.     Fellow of the Japanese Society of Internal Medicine (FJSIM), 2016

WORK & EDUCATION EXPERIENCE

2019-      Editorial board member; Scientific Reports

2018-      Associate Editorial board member; Frontiers in Cardiovascular Medicine

2018-      Editorial board member; J Mol Cell Cardiol

2017-     Member of the project for "Elucidating and Controlling Mechanisms of Aging and Longevity, Japan Agency for Medical Research and Development (AMED)".

2016-         Research chief of the ischemic heart disease and regenerative therapy group

                   Research chief of the heart failure group

2014-         Associate Professor, Department of Cardiovascular Biology and Medicine

                  Division of Molecular Aging and Cell Biology,

                  Niigata University Graduate School of Medical and Dental Sciences, Niigata Japan 

2013-2014 Boston University School of Medicine, Research Instructor of Medicine

2012-2013 Boston University School of Medicine, Whitaker Cardiovascular Institute, 

                   Molecular Cardiology, Postdoctoral Fellow, Boston, USA

2010-2012 Chiba University Hospital Department of Cardiology, Staff, Chiba, Japan

2006-2010 Doctoral coarse, Chiba University Graduate School of Medicine, Chiba, Japan

2004-2006 Sakakibara Heart Institute, Cardiovascular Internal Medicine, Tokyo, Japan

2002-2004 National Center for Global Health and Medicine, Tokyo, Japan

1996-2002 Chiba University Medical Department, Chiba, Japan

1996           Graduated from Senior High School at Komaba, University of Tsukuba, Tokyo, Japan

 

 

With Dr. Kenneth Walsh, March 2014, at Boston University.

SOCIETIES

1.     American Heart Association, Fellow (FAHA)

2.     European Society of Cardiology, Fellow (FESC)

3.     European Society of Cardiology, Working Group on Cellular Biology of the Heart

4.     European Society of Cardiology, Heart Failure Association regular membership

5.     Japanese Circulation Society

6.     Honorary member, Korean Society of Cardiology 2016.4.16-

7.     The Japanese Society of Internal Medicine

8.     International Society for Heart Research Japanese Section

9.     Society of Cardiovascular Endocrinology and Metabolism

10.  Japanese Society of Molecular Medicine

11.  The Japan Geriatrics Society

12.  The Japanese Society of Hypertension

13.  The Japanese Heart Failure Society

14.  Japan Society of the Study of Obesity

15.  Japanese Society for Circulation Research

16.  The Molecular Biology Society of Japan

17.  Japanese Society of Anti-Aging Medicine

18.  Japanese Association of Cardiovascular Intervention and Therapeutics

19.  Japanese Heart Rhythm Society

20.  Japanese College of Cardiology

21.  The Japanese Vascular Biology and Medicine Organization

SOCIETIES; Councilor

1.     Councilor; The Japanese Vascular Biology and Medicine Organization

2.     Councilor; Society of Cerebral-Cardio-Vascular Anti-Aging

3.     Councilor; The Japanese Onco-Cardiology Society

4.     Councilor; The Society of Cardiovascular Endocrinology and Metabolism (CVEM)

5.     Councilor; International Society for Heart Research (ISHR), Japanese Section

6.     Councilor; Japanese Circulation Society, Kantokoushinetsu Regional Office

7.     Councilor; NO society of Japan

8.     Councilor; Japanese Society of Anti-aging Medicine  

PUBLICATION

 1. Kim HK, Ko T, Song I, Jeong Y, Heo HJ, Jeong S, Kim M, Park NM, Seo DY, Kha PT, Kim SW, Lee SR, Cho SW, Won JC, Youm JB, Ko K, Rhee B, Kim N, Cho KI, Shimizu I, Minamino T, Ha NC, Park Y, Nilius B, Han J. BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes. Life Science Alliance (in press).

2. Fujiki S, Watanabe H, Obata H, Suda M, Mitsuma W, Tomii A, Sakai K, Uehara A, Shimizu I,, Kashimura T, Ozaki K, Minamino M. Association of adipokines with frailty in heart failure. Acta Bio Medica Atenei Parmensis. 2020 (in press).

3. Shimizu I,*, Minamino T*. Cellular senescence in arterial diseases. Journal of lipid and atherosclerosis. 2020 Jan;9(9(1):79-91 *Co-corresponding author

4. Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I,, Minamino T, Cho KI, Park YS, Kim S, Han J. Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis. 2019 Aug2; S0925-4439(19)30241-8

5. Shimizu I,*, Minamino T. Cellular senescence in cardiac diseases. J Cardiol. 2019 Jun 12; S0914-5087(19)30128-5 *Co-corresponding author

6. Yoshida Y*, Shimizu I,*, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagmi H, Morishita R, Minamino T. Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity. Sci Rep 2019 Mar7; 9(1)3858 *Co-first author

7. Yokoyama M*, Shimizu I,*, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol. 2019 Feb 18 *Co-first author

8. Wakasugi T*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Nakao M, Hoyano M Kashimura T, Nakamura K, Ito H, Nojiri T, Soga T, Minamino T. Role of smooth muscle cell p53 in pulmonary arterial hypertension. PLOS One. 2019 Feb 26, *Co-first author

9. Ikegami R*, Shimizu I,*,**, Sato T*, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen N, Scheele C, Soga T, Minamino T**. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic dysfunction in obesity. *Co-first author, **Co-corresponding author Cell Rep. 24(11):2827-2837, 2018

10. Furuuchi R*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLOS One. 13(8):e0202051, 2018. *Co-first author

11. Kayamori H, Shimizu I,, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T. Amlodipine inhibits vascular cell senescence and protects against atherogenesis through the mechanism independent of calcium channel blockade. Int Heart J. 2018 May 30;59(3):607-613

12. Katsuumi G*, Shimizu I,*, Yoshida Y, Minamino T. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med 05 March 2018 https://doi.org/10.3389/fcvm.2018.00018. *Co-first author

13. Ikegami R*, Shimizu I,*, Yoshida Y, Minamino T. Metabolomic analysis in heart failure. Circ J 2017 ;82(1):10-16 *Co-first author

14. Katsuumi G*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T. Catecholamine-induced cellular senescence in endothelium and bone-marrow cells promotes cardiac dysfunction in mice. Int Heart J. 2017 (in press) *Co-first author

15. Yoshida Y*, Shimizu I,*,**, Minamino T**. Diabetes and adipocyte dysfunction. Diabetes and Aging-related Complications, 2017, 69-84 (Springer publication). *Co-first author, **Co-corresponding author

16. Suda M*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of Dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. *Co-first author PLOS One 2017 Aug 3; 12(8), e0182422.

17. Suda M*, Shimizu I,*, Yoshida Y, Minamino T. Peripheral blood mononuclear cells for limb ischemia. Therapeutic Angiogenesis (Springer publication). p25-43, 2017, *Co-first author

18. Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yoshida Y, Tsuchida M, Iwama A, Hayano T and Tohru Minamino. Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. Oncotarget. 2017 May 23;8(21):34045-34056

19. Katsuumi G*, Shimizu I,*,**, Yoshida Y, Minamino T**. Inflammation and regeneration., The pathological role of cardio-vascular aging in heart failure. (in press) *Co-first author, **Co-corresponding author

20. Shimizu I,*, Minamino T*. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016 Jun 2;97:245-262 *Co-corresponding author

21. Maruyama S, Nakamura K, Papanicolaou N.K., Shimizu I,, Sano S, Asaumi Y, van den Hoff M.J., Ouchi N, Recchia A.F., Walsh K. EMBO Mol Med (in press) Follistatin-like 1 is an endogenous regulator of cardiac fibroblast activation that protects the heart from post-infarct rupture.

22. Shimizu I,, Yoshida Y, Minamino T. Hypertens Res (in press) A role for circadian clock in metabolic disease.

23. Nakamura K, Sano S, Fuster J, Kikuchi R, Shimizu I,, Ohshima K, Katanasaka Y, Ouchi N, and Walsh K. J Biol Chem. 2015 Feb 5;291(6):2566-75Sfrp5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury.

24. Shimizu I,, Yoshida Y, Minamino T. Diabetes. 2015 (Commentary) Dec;64(12):3984-6. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity.

25. Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I,, Miki T, Kobayashi Y, and Minamino T. Aging and Mechanism of Disease. (Nature publishing Group), 2015 October, Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation.

26. Yoshida Y*, Shimizu I,*, Minamino T. Inflammation and regeneration. 2015 September, The pathological role of adipose tissue aging in the progression of systemic insulin resistance. *Co-first author

27. Yoshida Y*, Shimizu I,*, Katsuumi G*, Jiao S, Suda M, Hayashi Y, Minamino T. J Mol Cell Cardiol. 2015 June 85:183-198. p53-induced inflammation exacerbates cardiac dysfunction during pressure overload. *Co-first author

28. Shimizu I,*, Yoshida Y, Minamino T*. Int Heart J. 2015 May 13;56(3):255-9. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders. *Co-corresponding author

29. Shimizu I,*, Walsh K. Curr Obes Rep. 2015 June 4;(2):224-229. Whitening of brown fat and implications for weight management in obesity. *Corresponding author

30. Shimizu I,, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab. 2014 Dec 2;20(6):967-977.

31. Kikuchi R, Nakamura K, Maclauchlan S, Ngo D, Shimizu I,, Fuster J, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi T, Matsushita T, Murohara T, Gokce N, Bates D, Hamburg N, Walsh K. An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. Nat Med. 2014 Nov2.

32. Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I,, Yoshino T, Katoh D, Nagoshi T , Tojo K, Minamino T, Yoshimura M, Utsunomiya K. Diabetes. 2014 Sep3. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy

33. Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I,, Minamino T. PLOS One. 2014; 9(6). Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway.

34. Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I,, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T. Cell Rep. 2014 June12, 7, 1-13. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.

35. Shimizu I,, Tamar A, Kikuchi R, Shimizu A, Papanicolaou K, Maclauchlan S, Maruyama S,Walsh K. J Clin Invest. 2014; Apr 4.Vascular rarefaction mediates whitening of brown fat in obesity.

36. Shimizu I,, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. Cell Metab 2013; 18:4. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. (Featured article)

37. Nojima A, Yamashita M, Yoshida Y, Shimizu I,, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii Naoaki, Minamino T. PLOS One. 2013; 30;8(7) Haploinsufficiency of Akt1 prolongs the lifespan of mice.

38. Shimizu I,, Walsh K. J Mol Cell Cardiol. 2013; 59C:176-178. Vascular remodeling mediated by Angptl2 produced from perivascular adipose tissue.

39. Shimizu I,, Yoshida Y, Katsuno T, Minamino T. Microbes and Infection. 2013; 1:11-7. Adipose tissue inflammation in diabetes and heart failure.

40. Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I,, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi T. J Hepatol. 2012; 57, 837-843. P53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.

41. Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I,, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Cell. 2012; 149: 1298-313. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes.

42. Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I,, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I. Arterioscler Thromb Vasc Biol. 2012; 8: 1902-9.  Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway.

43. Shimizu I,, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. Cell Metab. 2012; 15:51-64. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. (Featured article)

44. Yasuda N, Akazawa H, Ito K, Shimizu I,, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I. Hypertension. 2012; 59: 627-33. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.

45. Shimizu I,, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh G, Akazawa H, Shiojima I, Kahn C, Abel E, & Komuro I. J Clin Invest. 2010;120:1506-1514. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.

46. Moriya J, Minamino T, Tateno K, Okada S, Akiyoshi U. Shimizu I,, Yokoyama M, Nojima A, Henderson CE, Okada M, Koga H, Komuro I. Circ Res. 2010; 106:391-8. Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis.

47. Shimizu I,, Iguchi N, Watanabe H, Umemura J, Tobaru T, Asano R, Misu K, Nagayama M, Aikawa M Funabashi N, Komuro I, Sumiyoshi T. Int J Cardiol. 2010; 142:224-9. Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients.

48. Minamino T*, Orimo M*, Shimizu I,*, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. Nat Med. 2009; 15:1082-7. A crucial role for adipose tissue p53 in the regulation of insulin resistance. *Co-first author

49. Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I,, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H and Komuro I. J. Exp. Med. 2009; 206:1565-74. Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure.

50. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I,, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. Nature. 2007; 446:444-8. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.

ACADEMIC HONORS

2020 Catalyst Award, U.S. National Academy of Medicine, USA

2020 President’s Award, Niigata University, Japan

2016 Jokichi Takamine Young Investigator Award

2014 First Place, Young Investigator Competition of the 58th Annual Scientific Meeting. The

     Korean Society of Cardiology. Nov 28, 2014, Republic of Korea.

2014 President’s Award, Niigata University, Japan

2013 Best of the Day, Poster Award, XXI ISHR World Congress, 2013, July, USA

2013 Travel Award for the ISHR XXI World Congress, San Diego California, USA

2012 Winner, 2012 Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences,

    American Heart Association Scientific Sessions 2012, Los Angeles, USA

2012 Young Investigators Award, The 49th Annual Meeting of the Japanese Society of

    Molecular Medicine, Kyoto, Japan

2011 Outstanding Best Presenter Award, 12th US-Japan-Asia Dialogue on Cardiovascular Disease

    and Young Investigator Competition, Tokyo, Japan

2011 Chiba Medical Society Young Investigator Award, Japan

2011 Exceptional Poster Award, Miyazaki Science Camp, Japan

2011 Award for Excellence, 4th Frontier of Cardiovascular Disease and Metabolic Syndrome

     Research, Japan

2010 Young Investigators Award, The 27th Annual Scientific Session of the International Society

     for Heart Research, Japanese Division, Kyoto, Japan

2010 Young investigators Award, The 14th Annual Scientific Session of the Society of

    Cardiovascular Endocrinology and Metabolism, Nara, Japan

2010 Dean’s Award, Chiba University Graduate School of Medicine and Pharmaceutical Sciences,

    Japan

2010 President’s Award, Chiba University, Japan

2009 Outstanding achievement award (Prof. Issei Komuro) , Japan

2009 Young Investigator Award (highest award), 2nd Cardiovascular Aging and Metabolic

     Syndrome Symposium on the Pathophysiology of Cancer, Japan

INVITED LECTURES or PRESENTATIONS -INTERNATIONAL-

1.        Shimizu I. Symposium, American Diabetes Association 73rd Scientific Sessions. 2013, June21, Chicago, USA.Insulin resistance and cardiovascular diseases- A common pathophysiologic link through inflammation?

2.        Shimizu I, Walsh K, Minamino T. The 58th Annual Scientific Meeting of The Korean Society of Cardiology, 2014, Nov28, Goyang, Korea. Capillary rarefaction mediates whitening of brown fat and contributes to insulin resistance in obesity.

3.        Shimizu I, Invited lecture, Inje University, 2015, May6, Busan, Korea. The pathological role of adipose tissue dysfunction in cardio-metabolic disorders.

4.        Shimizu I, Symposium, 28th Spring Congress of Korean Diabetes Association, 2015, May7-9, Gwangju, Korea. The pathological role of aging signaling in heart failure.

5.        Shimizu I, Symposium, Annual Summer Symposium of the Basic Science study group, branch of the Korean Society of Cardiology, 2015, August 21-22, Osong, Korea. The pathological role of aging signaling in cardio-metabolic disorders.

6.        Shimizu I, Seminar, 2016, February 11, Rigshospitalet(Copenhagen University Hospital), Copenhagen, Denmark. Aging signaling promotes pathologies in cardio-metabolic disorders.

7.        Shimizu I, Invited lecture, Inje University, 2016, April14, Busan, Korea. The pathological role of a coagulation factor in promoting brown adipose tissue dysfunction and systemic metabolic disorder in obesity.

8.        Shimizu I, Symposium, Annual Spring Scientific Conference of the Korean Society of Cardiology in conjunction with KSIC, KSE, and KSLA & The 8th Asian Pacific Congress of Heart failure, 2016, April 15-16, Gyeongju, Korea. The role of adipose dysfunction in heart failure and obesity.

9.        Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Sato T, Minamino T. International Young Investigators (IYI) Presentation Session, 2016 Annual Meeting of Taiwan Society of Cardiology, May 13-15, 2016, Taipei, Taiwan. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders.

10.     Shimizu I, Yoshida Y, Minamino T. Symposium, The 9th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide (NO2016). 2016, May22, Sendai, Japan. The pathological role of adipose dysfunction in heart failure and obesity.

11.     Shimizu I, Minamino T. Invited lecture, Inje University, 2016, December 23, Busan, Korea, CMDC(Cardiovascular Metabolic Disease Center) Symposium. Fat dysfunction promotes pathologies in heart failure, obesity and diabetes.

12.     Shimizu I, Minamino T. Symposium, 2017 Annual Spring Scientific Conference of the KSC in conjunction with KSIC, KSE, KSLA, and KHRS. April 21-22, 2017, HICO, Gyeongju, Korea. Aging signaling promotes pathologies in heart failure.

13.     Shimizu I, Minamino T. Symposium, Conference on translational and therapeutic perspective of brown adipose, May2-4, Scandic Hotel, Copenhagen 2017. The pathological roles of brown adipose-tissue dysfunction in heart failure, obesity and diabetes.

14.     Shimizu I, Minamino T. Symposium, Korean Society for Biochemistry and Molecular Biology (KSBMB) International Conference 2017. May 19, Busan, Korea. The pathological roles of brown adipose-tissue dysfunction in age related disorders.

15.     Shimizu I, Yoshida Y, Minamino T. Symposium, KORUS Symposium 2017. June 28-29, Busan National Science Museum, Busan, Korea. Semaphorin3E is a novel therapeutic target for unhealthy obesity and diabetes.

16.     Shimizu I, Minamino T. Symposium, 23rd Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy (ISCP). May 27, 2018. The Ritz-Carlton, Kyoto. The pathologiacl role of brown adipose tissue dysfunction in cardio-metabolic disorders.

17.     Shimizu I, Yoshida Y, Minamino T. Symposium, Disoriented choline metabolism promotes pathologies in the failing heart. The 62nd Annual Scientific Meeting of The Korean Society of Cardiology, 2018, Oct11, Seoul, Korea.

18.     Shimizu I. Invited Lecture, Roles of aging signaling in cardiovascular-metabolic disorders. Department Pharmacology of Faculty of Medicine Universitas Indonesia (FMUI), 4th November, 2019, Jakarta, Indonesia.

19.     Shimizu I. Invited talk, Big data analysis for development of anti-aging medicine, Senolytic drug as a novel candidate for next anti-aging medicine. International Conference and Exhibition on Indonesian Medical Education and Research Institute (ICE ON IMERI), 4th November, 2019, IMERI building, Jakarta, Indonesia.

20.     Shimizu I. Invited Lecture, Pathogenic role of senometabolites in age-related disorders “Think aging” makes “Sync aging”. National Cardiovascular Center Harapan Kita, 5th November, 2019, Jakarta, Indonesia.

21.     Shimizu I, Minamino T. Senometabolite promotes pathologies in cardiovascular disorders.“Think aging” makes “Sync aging”. The 50th NIPS International Symposium, MIRACLES, in Cardiovascular Physiology. 5th December, 2019, Aichi, Japan

22.     Shimizu I. Invited Lecture, Pathogenic role of senocules in age-related disorders. Basic Cardiovascular Sciences (BCVS) 2020 Scientific Sessions, 29th July, 2020, Chicago, USA.

SCIENTIFIC MEETINGS -INTERNATIONAL-

1.        Shimizu I, Iguchi N, Watanabe H, Umemura J, Tobaru T, Asano R, Misu K, Nagayama M, Aikawa M, Komuro I, Sumiyoshi T. Poster presentation, ACC 55th Annual Scientific Session. 2006, March11-14, Atlanta, USA. Late gadolinium enhanced cardiovascular magnetic resonance as a novel technique to predict major adverse cardiac events in patients with left ventricular systolic dysfunction without obstructive coronary artery disease.

2.        Shimizu I, Minamino T, Komuro I. Poster presentation, Aging, Biology of Gordon research conference. 2009, February15-20, Ventura, Los Angeles, USA. Excessive activation of the insulin signal pathway in the heart causes deterioration of cardiac function during pressure overload.

3.        Shimizu I, Minamino T, Komuro I. Poster presentation, Basic Cardiovascular Sciences Scientific Sessions (BCVS), Molecular Mechanisms of Cardiovascular Disease. 2009, July20-23, Nevada, Lake Las Vegas, USA. Excessive activation of the insulin signal pathway in the heart deteriorates cardiac function during pressure overload.

4.        Shimizu I, Oral presentation, Young Investigator Award Competition, The 12th US-Japan-Asia Dialogue on Cardiovascular Diseases and Young Investigator Competetion, 2011, July, Tokyo Japan, Adipose p53 is critically involved in the development of insulin resistance in heart failure

5.        Shimizu I, Yoshida Y, Katsuno T, Minamino T. Poster presentation, Aging, Biology of Gordon research conference. 2012, February12-17, Ventura, Los Angeles, USA. Adipose p53 is critically involved in the development of insulin resistance in heart failure.

6.        Shimizu I, Yoshida Y, Katsuno T, Kobayashi Y, Minamino T. Poster presentation, Basic Cardiovascular Sciences Scientific Sessions (BCVS), 2012, July23, New Orleans, USA. Inhibition of adipose inflammation as a novel therapeutic target for heart failure.

7.        Shimizu I, Yoshida Y, Moriya J, Katsuno T, Suda M, Kobayashi Y, Minamino T. Oral presentation, Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences. American Heart Association, Scientific Sessions. 2012, Nov4, Los Angeles, USA. Semaphorin-Induced Inflammation Contributes To Insulin Resistance in Dietary Obesity.

8.        Shimizu I, Yoshida Y, Moriya J, Minamino T. Poster presentation, The 30th Annual Meeting of the International Society for Heart Research Japanese Section. 2013, June29, San Diego, USA. The crucial role for semaphorin in adipose inflammation and systemic insulin resistance in obesity

9.        Shimizu I, Yoshida Y, Moriya J, Minamino T. Poster presentation, XXI ISHR World Congress, 2013, July1, San Diego, USA. The crucial role for semaphorin in adipose inflammation and systemic insulin resistance in obesity

10.     Shimizu I, Walsh K. Poster presentation, 2014 Keystone Symposia Conference, Mitochondrial Dynamics and Physiology, 2014, Feb21, Santa Fe, New Mexico, USA. Capillary rarefaction mediates whitening of brown fat and contributes to insulin resistance in dietary obesity

11.     Shimizu I, Walsh K. Poster presentation, European Society of Cardiology Congress, 2014, Aug31, Barcelona, Spain. Vascular rarefaction mediates whitening of brown fat in obesity

12.     Shimizu I, Walsh K. Poster presentation, The ESC Council on Basic Cardiovascular Science, 2014, Aug31, Barcelona, Spain. Vascular rarefaction mediates whitening of brown fat in obesity

13.     Shimizu I, Hayashi Y, Yoshida Y, Suda M, Ikegami R, Katsuumi G, Kayamori H, Jiao S, Minamino T, Poster presentation, Keystone Symposia Conference, Diabetes, New Insight into Molecular Mechanisms and Therapeutic Strategies, 2015, Oct28, Kyoto, Japan. FactorXa inhibits brown adipose tissue function and induces systemic metabolic dysfunction in obesity.

14.     Shimizu I, Yoshida Y, Nakagami H, Kamimura K, Terai S, Minamino T, Poster presentation, Obesity associated pro-fibrotic protein promotes pathologies in non-alcoholic steatohepatitis. Asia-Pacific Diabetes and Obesity Study Group, SYMPOSIUM 2018, 2018, Oct 8th, Kobe Convention Center.

15.     Shimizu I, Yoshida Y, Ikegami R, Minamino T. Poster presentation, Basic Cardiovascular Sciences Scientific Sessions (BCVS) 2019, 2019, July 29-Aug1, Boston, USA. Pathological roles of senometabolites in cardiovascular disorders.

16.     Shimizu I, Yoshida Y, Minamino T, oral presentation, American Heart Association, Scientific Sessions. 2019, Nov18, Pennsylvania Convention Center, Pennsylvania, USA.

17.     Shimizu I, Yoshida Y, Yung Ting Hsiao, Minamino T, poster presentation, Senometabolite contributes for synchronization of aging and promotes pathologies related with aging or age-related diseases, Keystone sympsia, 2020 Feb 9-13, Fairmont Hotel Vancouver, Canada.

 

INVITED LECTURES or PRESENTATIONS - Japan -

Totally 89 presentation.

Here, I would like to thank the organizers for giving me these great opportunities.

SCIENTIFIC MEETINGS - Japan -

Totally 51 presentation.

GRANTS2019  2019

2020 The Cell Science Research Foundation

2019 Astellas Foundation for Research on Metabolic Disorders

2019 Mochida Memorial Foundation for Medical & Pharmaceutical Research

2019 JSPS KAKENHI, Grant-in-Aid for Challenging Exploratory Research

2019 Grants-in-Aid for Scientific Researcher(B)

2019 The Japan Geriatrics Society, Research Representative

2019 The Naito Foundation, Research Representative

2017 Elucidating and Controlling Mechanisms of Aging and Longevity, Japan Agency for Medical Research and Development (AMED)".

2017 Takeda Science Foundation, Research Representative

2017 Grant-in-Aid for Challenging Exploratory Research, Research Representative

2016 The Uehara Memorial Foundation, Research Representative

2016 Daiichi Sankyo Foundation of Life Science

2016 TERUMO FOUNDATION for LIFE SCIENCES and ARTS

2016 Kimura Memorial Heart Foundation, Research Representative

2016 Japan Diabetes Foundation, Research Representative

2016 The Bayer Scholarship for Cardiovascular Research, Research Representative

2016 Grants-in-Aid for Encouragement of Young Scientists (A) (JSPS KAKENHI Grant Number 16H06244) , Research Representative

2016 Inamori Foundation, Research Representative

2015 SENSHIN Medical Research Foundation, Research Representative

2015 Kanae Foundation Research Grant, Research Representative

2015 Grant for Basic Science Research Projects from The Sumitomo Foundation, Research Representative

2015 Banyu Foundation Research Grant, Research Representative

2015 Tsukada Grant for Niigata University Medical Research, Research Representative

2014 Japan Heart Foundation Research Grant, Research Representative

2014 The Uehara Memorial Foundation, Research Representative

2014 ONO Medical Research Foundation, Research Representative

2014 The Senri Life Science Foundation, Research Representative

2014 The Nakajima Foundation, Research Representative

2014 SENSHIN Medical Research Foundation, Research Representative

2014 Kowa Life Science Foundation, Research Representative

2014 SUZUKEN memorial foundation, Research Representative

2014 HOKUTO Corporation, Research Representative

2014 Grants-in-Aid for Young Scientists (Start-up) (KAKENHI) 26893080, Research

     Representative

2014 Mochida Memorial Foundation for Medical & Pharmaceutical Research, Research 

     Representative

2013 Aging and geriatrics Novartis research foundation, exchanges overseas research grant,

     Research Representative

2012 Manpei Suzuki Diabetes foundation, Research Representative

2012 Kanae Foundation for the Promotion of Medical Science, Research Representative

2011 Japan Heart Foundation/Novartis Research Award on Molecular and Cellular Cardiology,

     Research Representative

2011 Kowa Life Science Foundation, Research Representative

2011 The Uehara Memorial Foundation, Research Representative

2011 Japan Society for the promotion of science, Grant-in-Aid for Young Scientists (B), Research

     Representative

2011 Takeda Science Foundation, Research Representative

2010 Novartis research foundation, Research Representative

LECTURES

Instructor of case study for 3rd grade medical student, 1/10/2020

Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 1/6/2020

 

Instructor of case study for 3rd grade medical student, 12/14/2018

Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 12/14/2018

Adjunct instructor, Kumamoto University, 2018

Adjunct instructor, Nagoya University, 2017

Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 11/27/2017

Lecture for 2nd grade medical student, Physiological and pathological hypertrophy. 6/16/2017

Evaluator of Objective structured clinical examination (OSCE) for 4th grade medical student. 1/28/2017

Evaluator of simulated Objective structured clinical examination (OSCE) for 4th grade medical student. 1/17/2017

Instructor of Objective structured clinical examination (OSCE), clinical examination of vital check for 4th grade medical student. 12/19/2016

Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 9/29/2016

Instructor of case study for 3rd grade medical student, dyspnea and palpitation. 9/29/2016

Instructor of case study for 3rd grade medical student, chest pain. 10/16/2015

Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 10/15/2015

Instructor of case study for 3rd grade medical student, palpitation. 10/23/2014

Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 10/15/2014

 

ACADEMIC AND RESEARCH INTERESTS

Cardiovascular diseases, Heart failure, Obesity, Diabetes, Systemic insulin resistance, Chronic inflammation, Metabolism, Brown adipose tissue, Aging, Adipokines, Sympathetic nervous system

VOLUNTEER WORKS

Medical assistant team for Minamisanriku Miyagi, 2-6/April/2011

(Great East Japan Earthquake March/11th /2011)