Molecular Aging and Cell Biology
IPPEI SHIMIZU M.D., Ph.D. FESC. FAHA
Associate Professor
Department of Cardiovascular Biology and Medicine,
Division of Molecular Aging and Cell Biology
Research chief of the ischemic heart disease and regenerative therapy group
Research chief of the heart failure group
Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
・Member of the project for "Elucidating and Controlling Mechanisms of Aging and Longevity, Japan Agency for Medical Research and Development (AMED)".
・Associate Editorial board member; Frontiers in Cardiovascular Medicine
・Editorial board member; Scientific Reports, J Mol Cell Cardiol
・Fellow; European Society of Cardiology (FESC)
・Fellow; American Heart Association (FAHA)
ORCID ID; https://orcid.org/0000-0003-3333-8131
Loop profile: 490714
Scopus Author ID: 7202212470
E-mail: ippeishimizu[at]yahoo.co.jp / ippeishimizu[at]med.niigata-u.ac.jp
Please replace [at] with @ when contacting us.
QUALIFICATIONS
1. Board Certified Member of the Japanese Society of Internal Medicine, 2005
2. Cardiovascular Specialist of Japanese Circulation Society, 2009
3. Doctor of Philosophy, 2010
4. Fellow of the Japanese Society of Internal Medicine (FJSIM), 2016
WORK & EDUCATION
EXPERIENCE
2019- Editorial board member; Scientific Reports
2018- Associate Editorial board member; Frontiers in Cardiovascular Medicine
2018- Editorial board member; J Mol Cell Cardiol
2017- Member of the project for "Elucidating and Controlling Mechanisms of Aging and Longevity, Japan Agency for Medical Research and Development (AMED)".
2016- Research chief of the ischemic heart disease and regenerative therapy group
Research chief of the heart failure group
2014- Associate Professor, Department of Cardiovascular Biology and Medicine
Division
of Molecular Aging and Cell Biology,
Niigata University Graduate School of Medical and Dental Sciences, Niigata Japan
2013-2014 Boston University School of Medicine, Research Instructor of Medicine
2012-2013 Boston University School of Medicine, Whitaker Cardiovascular Institute,
Molecular Cardiology, Postdoctoral Fellow, Boston, USA
2010-2012 Chiba University Hospital Department of Cardiology, Staff, Chiba, Japan
2006-2010 Doctoral coarse, Chiba University Graduate School of Medicine, Chiba, Japan
2004-2006 Sakakibara Heart Institute, Cardiovascular Internal Medicine, Tokyo, Japan
2002-2004 National Center for Global Health and Medicine, Tokyo, Japan
1996-2002 Chiba University Medical Department, Chiba, Japan
1996 Graduated from Senior High School at Komaba, University of Tsukuba, Tokyo, Japan
With Dr.
Kenneth Walsh, March 2014, at Boston University.
SOCIETIES
1. American Heart Association, Fellow (FAHA)
2. European Society of Cardiology, Fellow (FESC)
3. European Society of Cardiology, Working Group on Cellular Biology of the Heart
4. European Society of Cardiology, Heart Failure Association regular membership
5. Japanese Circulation Society
6. Honorary member, Korean Society of Cardiology 2016.4.16-
7. The Japanese Society of Internal Medicine
8. International Society for Heart Research Japanese Section
9. Society of Cardiovascular Endocrinology and Metabolism
10. Japanese Society of Molecular Medicine
11. The Japan Geriatrics Society
12. The Japanese Society of Hypertension
13. The Japanese Heart Failure Society
14. Japan Society of the Study of Obesity
15. Japanese Society for Circulation Research
16. The Molecular Biology Society of Japan
17. Japanese Society of Anti-Aging Medicine
18. Japanese Association of Cardiovascular Intervention and Therapeutics
19. Japanese Heart Rhythm Society
20. Japanese College of Cardiology
21. The Japanese Vascular Biology and Medicine Organization
SOCIETIES; Councilor
1. Councilor; The Japanese Vascular Biology and Medicine Organization
2. Councilor; Society of Cerebral-Cardio-Vascular Anti-Aging
3. Councilor; The Japanese Onco-Cardiology Society
4. Councilor; The Society of Cardiovascular Endocrinology and Metabolism (CVEM)
5. Councilor; International Society for Heart Research (ISHR), Japanese Section
6. Councilor; Japanese Circulation Society, Kantokoushinetsu Regional Office
7. Councilor; NO society of Japan
8. Councilor; Japanese Society of Anti-aging Medicine
PUBLICATION
1. Kim HK, Ko T, Song I, Jeong Y, Heo HJ, Jeong S, Kim M, Park NM, Seo DY, Kha PT, Kim SW, Lee SR, Cho SW, Won JC, Youm JB, Ko K, Rhee B, Kim N, Cho KI, Shimizu I, Minamino T, Ha NC, Park Y, Nilius B, Han J. BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes. Life Science Alliance (in press).
2. Fujiki S, Watanabe H, Obata H, Suda M, Mitsuma W, Tomii A, Sakai K, Uehara A, Shimizu I,, Kashimura T, Ozaki K, Minamino M. Association of adipokines with frailty in heart failure. Acta Bio Medica Atenei Parmensis. 2020 (in press).
3. Shimizu I,*, Minamino T*. Cellular senescence in arterial diseases. Journal of lipid and atherosclerosis. 2020 Jan;9(9(1):79-91 *Co-corresponding author
4. Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I,, Minamino T, Cho KI, Park YS, Kim S, Han J. Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis. 2019 Aug2; S0925-4439(19)30241-8
5. Shimizu I,*, Minamino T. Cellular senescence in cardiac diseases. J Cardiol. 2019 Jun 12; S0914-5087(19)30128-5 *Co-corresponding author
6. Yoshida Y*, Shimizu I,*, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagmi H, Morishita R, Minamino T. Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity. Sci Rep 2019 Mar7; 9(1)3858 *Co-first author
7. Yokoyama M*, Shimizu I,*, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol. 2019 Feb 18 *Co-first author
8. Wakasugi T*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Nakao M, Hoyano M Kashimura T, Nakamura K, Ito H, Nojiri T, Soga T, Minamino T. Role of smooth muscle cell p53 in pulmonary arterial hypertension. PLOS One. 2019 Feb 26, *Co-first author
9. Ikegami R*, Shimizu I,*,**, Sato T*, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen N, Scheele C, Soga T, Minamino T**. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic dysfunction in obesity. *Co-first author, **Co-corresponding author Cell Rep. 24(11):2827-2837, 2018
10. Furuuchi R*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLOS One. 13(8):e0202051, 2018. *Co-first author
11. Kayamori H, Shimizu I,, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T. Amlodipine inhibits vascular cell senescence and protects against atherogenesis through the mechanism independent of calcium channel blockade. Int Heart J. 2018 May 30;59(3):607-613
12. Katsuumi G*, Shimizu I,*, Yoshida Y, Minamino T. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med 05 March 2018 https://doi.org/10.3389/fcvm.2018.00018. *Co-first author
13. Ikegami R*, Shimizu I,*, Yoshida Y, Minamino T. Metabolomic analysis in heart failure. Circ J 2017 ;82(1):10-16 *Co-first author
14. Katsuumi G*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T. Catecholamine-induced cellular senescence in endothelium and bone-marrow cells promotes cardiac dysfunction in mice. Int Heart J. 2017 (in press) *Co-first author
15. Yoshida Y*, Shimizu I,*,**, Minamino T**. Diabetes and adipocyte dysfunction. Diabetes and Aging-related Complications, 2017, 69-84 (Springer publication). *Co-first author, **Co-corresponding author
16. Suda M*, Shimizu I,*, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of Dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. *Co-first author PLOS One 2017 Aug 3; 12(8), e0182422.
17. Suda M*, Shimizu I,*, Yoshida Y, Minamino T. Peripheral blood mononuclear cells for limb ischemia. Therapeutic Angiogenesis (Springer publication). p25-43, 2017, *Co-first author
18. Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yoshida Y, Tsuchida M, Iwama A, Hayano T and Tohru Minamino. Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. Oncotarget. 2017 May 23;8(21):34045-34056
19. Katsuumi G*, Shimizu I,*,**, Yoshida Y, Minamino T**. Inflammation and regeneration., The pathological role of cardio-vascular aging in heart failure. (in press) *Co-first author, **Co-corresponding author
20. Shimizu I,*, Minamino T*. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016 Jun 2;97:245-262 *Co-corresponding author
21. Maruyama S, Nakamura K, Papanicolaou N.K., Shimizu I,, Sano S, Asaumi Y, van den Hoff M.J., Ouchi N, Recchia A.F., Walsh K. EMBO Mol Med (in press) Follistatin-like 1 is an endogenous regulator of cardiac fibroblast activation that protects the heart from post-infarct rupture.
22. Shimizu I,, Yoshida Y, Minamino T. Hypertens Res (in press) A role for circadian clock in metabolic disease.
23. Nakamura K, Sano S, Fuster J, Kikuchi R, Shimizu I,, Ohshima K, Katanasaka Y, Ouchi N, and Walsh K. J Biol Chem. 2015 Feb 5;291(6):2566-75Sfrp5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury.
24. Shimizu I,, Yoshida Y, Minamino T. Diabetes. 2015 (Commentary) Dec;64(12):3984-6. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity.
25. Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I,, Miki T, Kobayashi Y, and Minamino T. Aging and Mechanism of Disease. (Nature publishing Group), 2015 October, Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation.
26. Yoshida Y*, Shimizu I,*, Minamino T. Inflammation and regeneration. 2015 September, The pathological role of adipose tissue aging in the progression of systemic insulin resistance. *Co-first author
27. Yoshida Y*, Shimizu I,*, Katsuumi G*, Jiao S, Suda M, Hayashi Y, Minamino T. J Mol Cell Cardiol. 2015 June 85:183-198. p53-induced inflammation exacerbates cardiac dysfunction during pressure overload. *Co-first author
28. Shimizu I,*, Yoshida Y, Minamino T*. Int Heart J. 2015 May 13;56(3):255-9. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders. *Co-corresponding author
29. Shimizu I,*, Walsh K. Curr Obes Rep. 2015 June 4;(2):224-229. Whitening of brown fat and implications for weight management in obesity. *Corresponding author
30. Shimizu I,, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab. 2014 Dec 2;20(6):967-977.
31. Kikuchi R, Nakamura K, Maclauchlan S, Ngo D, Shimizu I,, Fuster J, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi T, Matsushita T, Murohara T, Gokce N, Bates D, Hamburg N, Walsh K. An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. Nat Med. 2014 Nov2.
32. Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I,, Yoshino T, Katoh D, Nagoshi T , Tojo K, Minamino T, Yoshimura M, Utsunomiya K. Diabetes. 2014 Sep3. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy
33. Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I,, Minamino T. PLOS One. 2014; 9(6). Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway.
34. Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I,, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T. Cell Rep. 2014 June12, 7, 1-13. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.
35. Shimizu I,, Tamar A, Kikuchi R, Shimizu A, Papanicolaou K, Maclauchlan S, Maruyama S,Walsh K. J Clin Invest. 2014; Apr 4.Vascular rarefaction mediates whitening of brown fat in obesity.
36. Shimizu I,, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. Cell Metab 2013; 18:4. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. (Featured article)
37. Nojima A, Yamashita M, Yoshida Y, Shimizu I,, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii Naoaki, Minamino T. PLOS One. 2013; 30;8(7) Haploinsufficiency of Akt1 prolongs the lifespan of mice.
38. Shimizu I,, Walsh K. J Mol Cell Cardiol. 2013; 59C:176-178. Vascular remodeling mediated by Angptl2 produced from perivascular adipose tissue.
39. Shimizu I,, Yoshida Y, Katsuno T, Minamino T. Microbes and Infection. 2013; 1:11-7. Adipose tissue inflammation in diabetes and heart failure.
40. Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I,, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi T. J Hepatol. 2012; 57, 837-843. P53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
41. Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I,, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Cell. 2012; 149: 1298-313. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes.
42. Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I,, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I. Arterioscler Thromb Vasc Biol. 2012; 8: 1902-9. Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway.
43. Shimizu I,, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. Cell Metab. 2012; 15:51-64. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. (Featured article)
44. Yasuda N, Akazawa H, Ito K, Shimizu I,, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I. Hypertension. 2012; 59: 627-33. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.
45. Shimizu I,, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh G, Akazawa H, Shiojima I, Kahn C, Abel E, & Komuro I. J Clin Invest. 2010;120:1506-1514. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
46. Moriya J, Minamino T, Tateno K, Okada S, Akiyoshi U. Shimizu I,, Yokoyama M, Nojima A, Henderson CE, Okada M, Koga H, Komuro I. Circ Res. 2010; 106:391-8. Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis.
47. Shimizu I,, Iguchi N, Watanabe H, Umemura J, Tobaru T, Asano R, Misu K, Nagayama M, Aikawa M Funabashi N, Komuro I, Sumiyoshi T. Int J Cardiol. 2010; 142:224-9. Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients.
48. Minamino T*, Orimo M*, Shimizu I,*, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. Nat Med. 2009; 15:1082-7. A crucial role for adipose tissue p53 in the regulation of insulin resistance. *Co-first author
49. Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I,, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H and Komuro I. J. Exp. Med. 2009; 206:1565-74. Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure.
50. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I,, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. Nature. 2007; 446:444-8. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.
ACADEMIC HONORS
2016 Jokichi Takamine Young Investigator Award
2014 First Place, Young Investigator Competition of the 58th Annual Scientific Meeting. The
Korean Society of Cardiology. Nov 28, 2014, Republic of Korea.
2014 President’s Award, Niigata University, Japan
2013 Best of the Day, Poster Award, XXI ISHR World Congress, 2013, July, USA
2013 Travel Award for the ISHR XXI World Congress, San Diego California, USA
2012 Winner, 2012 Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences,
American Heart Association Scientific Sessions 2012, Los Angeles, USA
2012 Young Investigators Award, The 49th Annual Meeting of the Japanese Society of
Molecular Medicine, Kyoto, Japan
2011 Outstanding Best Presenter Award, 12th US-Japan-Asia Dialogue on Cardiovascular Disease
and Young Investigator Competition, Tokyo, Japan
2011 Chiba Medical Society Young Investigator Award, Japan
2011 Exceptional Poster Award, Miyazaki Science Camp, Japan
2011 Award for Excellence, 4th Frontier of Cardiovascular Disease and Metabolic Syndrome
Research, Japan
2010 Young Investigators Award, The 27th Annual Scientific Session of the International Society
for Heart Research, Japanese Division, Kyoto, Japan
2010 Young investigators Award, The 14th Annual Scientific Session of the Society of
Cardiovascular Endocrinology and Metabolism, Nara, Japan
2010 Dean’s Award, Chiba University Graduate School of Medicine and Pharmaceutical Sciences,
Japan
2010 President’s Award, Chiba University, Japan
2009 Outstanding achievement award (Prof. Issei Komuro) , Japan
2009 Young Investigator Award (highest award), 2nd Cardiovascular Aging and Metabolic
Syndrome Symposium on the Pathophysiology of Cancer, Japan
INVITED LECTURES or PRESENTATIONS -INTERNATIONAL-
1. Shimizu I. Symposium, American Diabetes Association 73rd Scientific Sessions. 2013, June21, Chicago, USA.Insulin resistance and cardiovascular diseases- A common pathophysiologic link through inflammation?
2. Shimizu I, Walsh K, Minamino T. The 58th Annual Scientific Meeting of The Korean Society of Cardiology, 2014, Nov28, Goyang, Korea. Capillary rarefaction mediates whitening of brown fat and contributes to insulin resistance in obesity.
3. Shimizu I, Invited lecture, Inje University, 2015, May6, Busan, Korea. The pathological role of adipose tissue dysfunction in cardio-metabolic disorders.
4. Shimizu I, Symposium, 28th Spring Congress of Korean Diabetes Association, 2015, May7-9, Gwangju, Korea. The pathological role of aging signaling in heart failure.
5. Shimizu I, Symposium, Annual Summer Symposium of the Basic Science study group, branch of the Korean Society of Cardiology, 2015, August 21-22, Osong, Korea. The pathological role of aging signaling in cardio-metabolic disorders.
6. Shimizu I, Seminar, 2016, February 11, Rigshospitalet(Copenhagen University Hospital), Copenhagen, Denmark. Aging signaling promotes pathologies in cardio-metabolic disorders.
7. Shimizu I, Invited lecture, Inje University, 2016, April14, Busan, Korea. The pathological role of a coagulation factor in promoting brown adipose tissue dysfunction and systemic metabolic disorder in obesity.
8. Shimizu I, Symposium, Annual Spring Scientific Conference of the Korean Society of Cardiology in conjunction with KSIC, KSE, and KSLA & The 8th Asian Pacific Congress of Heart failure, 2016, April 15-16, Gyeongju, Korea. The role of adipose dysfunction in heart failure and obesity.
9. Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Sato T, Minamino T. International Young Investigators (IYI) Presentation Session, 2016 Annual Meeting of Taiwan Society of Cardiology, May 13-15, 2016, Taipei, Taiwan. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders.
10. Shimizu I, Yoshida Y, Minamino T. Symposium, The 9th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide (NO2016). 2016, May22, Sendai, Japan. The pathological role of adipose dysfunction in heart failure and obesity.
11. Shimizu I, Minamino T. Invited lecture, Inje University, 2016, December 23, Busan, Korea, CMDC(Cardiovascular Metabolic Disease Center) Symposium. Fat dysfunction promotes pathologies in heart failure, obesity and diabetes.
12. Shimizu I, Minamino T. Symposium, 2017 Annual Spring Scientific Conference of the KSC in conjunction with KSIC, KSE, KSLA, and KHRS. April 21-22, 2017, HICO, Gyeongju, Korea. Aging signaling promotes pathologies in heart failure.
13. Shimizu I, Minamino T. Symposium, Conference on translational and therapeutic perspective of brown adipose, May2-4, Scandic Hotel, Copenhagen 2017. The pathological roles of brown adipose-tissue dysfunction in heart failure, obesity and diabetes.
14. Shimizu I, Minamino T. Symposium, Korean Society for Biochemistry and Molecular Biology (KSBMB) International Conference 2017. May 19, Busan, Korea. The pathological roles of brown adipose-tissue dysfunction in age related disorders.
15. Shimizu I, Yoshida Y, Minamino T. Symposium, KORUS Symposium 2017. June 28-29, Busan National Science Museum, Busan, Korea. Semaphorin3E is a novel therapeutic target for unhealthy obesity and diabetes.
16. Shimizu I, Minamino T. Symposium, 23rd Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy (ISCP). May 27, 2018. The Ritz-Carlton, Kyoto. The pathologiacl role of brown adipose tissue dysfunction in cardio-metabolic disorders.
17. Shimizu I, Yoshida Y, Minamino T. Symposium, Disoriented choline metabolism promotes pathologies in the failing heart. The 62nd Annual Scientific Meeting of The Korean Society of Cardiology, 2018, Oct11, Seoul, Korea.
18. Shimizu I. Invited Lecture, Roles of aging signaling in cardiovascular-metabolic disorders. Department Pharmacology of Faculty of Medicine Universitas Indonesia (FMUI), 4th November, 2019, Jakarta, Indonesia.
19. Shimizu I. Invited talk, Big data analysis for development of anti-aging medicine, Senolytic drug as a novel candidate for next anti-aging medicine. International Conference and Exhibition on Indonesian Medical Education and Research Institute (ICE ON IMERI), 4th November, 2019, IMERI building, Jakarta, Indonesia.
20. Shimizu I. Invited Lecture, Pathogenic role of senometabolites in age-related disorders “Think aging” makes “Sync aging”. National Cardiovascular Center Harapan Kita, 5th November, 2019, Jakarta, Indonesia.
21. Shimizu I, Minamino T. Senometabolite promotes pathologies in cardiovascular disorders.“Think aging” makes “Sync aging”. The 50th NIPS International Symposium, MIRACLES, in Cardiovascular Physiology. 5th December, 2019, Aichi, Japan
22. Shimizu I. Invited Lecture, Pathogenic role of senocules in age-related disorders. Basic Cardiovascular Sciences (BCVS) 2020 Scientific Sessions, 29th July, 2020, Chicago, USA.
SCIENTIFIC MEETINGS -INTERNATIONAL-
1. Shimizu I, Iguchi N, Watanabe H, Umemura J, Tobaru T, Asano R, Misu K, Nagayama M, Aikawa M, Komuro I, Sumiyoshi T. Poster presentation, ACC 55th Annual Scientific Session. 2006, March11-14, Atlanta, USA. Late gadolinium enhanced cardiovascular magnetic resonance as a novel technique to predict major adverse cardiac events in patients with left ventricular systolic dysfunction without obstructive coronary artery disease.
2. Shimizu I, Minamino T, Komuro I. Poster presentation, Aging, Biology of Gordon research conference. 2009, February15-20, Ventura, Los Angeles, USA. Excessive activation of the insulin signal pathway in the heart causes deterioration of cardiac function during pressure overload.
3. Shimizu I, Minamino T, Komuro I. Poster presentation, Basic Cardiovascular Sciences Scientific Sessions (BCVS), Molecular Mechanisms of Cardiovascular Disease. 2009, July20-23, Nevada, Lake Las Vegas, USA. Excessive activation of the insulin signal pathway in the heart deteriorates cardiac function during pressure overload.
4. Shimizu I, Oral presentation, Young Investigator Award Competition, The 12th US-Japan-Asia Dialogue on Cardiovascular Diseases and Young Investigator Competetion, 2011, July, Tokyo Japan, Adipose p53 is critically involved in the development of insulin resistance in heart failure
5. Shimizu I, Yoshida Y, Katsuno T, Minamino T. Poster presentation, Aging, Biology of Gordon research conference. 2012, February12-17, Ventura, Los Angeles, USA. Adipose p53 is critically involved in the development of insulin resistance in heart failure.
6. Shimizu I, Yoshida Y, Katsuno T, Kobayashi Y, Minamino T. Poster presentation, Basic Cardiovascular Sciences Scientific Sessions (BCVS), 2012, July23, New Orleans, USA. Inhibition of adipose inflammation as a novel therapeutic target for heart failure.
7. Shimizu I, Yoshida Y, Moriya J, Katsuno T, Suda M, Kobayashi Y, Minamino T. Oral presentation, Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences. American Heart Association, Scientific Sessions. 2012, Nov4, Los Angeles, USA. Semaphorin-Induced Inflammation Contributes To Insulin Resistance in Dietary Obesity.
8. Shimizu I, Yoshida Y, Moriya J, Minamino T. Poster presentation, The 30th Annual Meeting of the International Society for Heart Research Japanese Section. 2013, June29, San Diego, USA. The crucial role for semaphorin in adipose inflammation and systemic insulin resistance in obesity
9. Shimizu I, Yoshida Y, Moriya J, Minamino T. Poster presentation, XXI ISHR World Congress, 2013, July1, San Diego, USA. The crucial role for semaphorin in adipose inflammation and systemic insulin resistance in obesity
10. Shimizu I, Walsh K. Poster presentation, 2014 Keystone Symposia Conference, Mitochondrial Dynamics and Physiology, 2014, Feb21, Santa Fe, New Mexico, USA. Capillary rarefaction mediates whitening of brown fat and contributes to insulin resistance in dietary obesity
11. Shimizu I, Walsh K. Poster presentation, European Society of Cardiology Congress, 2014, Aug31, Barcelona, Spain. Vascular rarefaction mediates whitening of brown fat in obesity
12. Shimizu I, Walsh K. Poster presentation, The ESC Council on Basic Cardiovascular Science, 2014, Aug31, Barcelona, Spain. Vascular rarefaction mediates whitening of brown fat in obesity
13. Shimizu I, Hayashi Y, Yoshida Y, Suda M, Ikegami R, Katsuumi G, Kayamori H, Jiao S, Minamino T, Poster presentation, Keystone Symposia Conference, Diabetes, New Insight into Molecular Mechanisms and Therapeutic Strategies, 2015, Oct28, Kyoto, Japan. FactorXa inhibits brown adipose tissue function and induces systemic metabolic dysfunction in obesity.
14. Shimizu I, Yoshida Y, Nakagami H, Kamimura K, Terai S, Minamino T, Poster presentation, Obesity associated pro-fibrotic protein promotes pathologies in non-alcoholic steatohepatitis. Asia-Pacific Diabetes and Obesity Study Group, SYMPOSIUM 2018, 2018, Oct 8th, Kobe Convention Center.
15. Shimizu I, Yoshida Y, Ikegami R, Minamino T. Poster presentation, Basic Cardiovascular Sciences Scientific Sessions (BCVS) 2019, 2019, July 29-Aug1, Boston, USA. Pathological roles of senometabolites in cardiovascular disorders.
16. Shimizu I, Yoshida Y, Minamino T, oral presentation, American Heart Association, Scientific Sessions. 2019, Nov18, Pennsylvania Convention Center, Pennsylvania, USA.
17. Shimizu I, Yoshida Y, Yung Ting Hsiao, Minamino T, poster presentation, Senometabolite contributes for synchronization of aging and promotes pathologies related with aging or age-related diseases, Keystone sympsia, 2020 Feb 9-13, Fairmont Hotel Vancouver, Canada.
INVITED LECTURES or PRESENTATIONS - Japan -
Totally 89 presentation.
Here, I would like to thank the organizers for giving me these great opportunities.
SCIENTIFIC MEETINGS - Japan -
Totally 51 presentation.
GRANTS2019 2019
2020 The Cell Science Research Foundation
2019 Astellas Foundation for Research on Metabolic Disorders
2019 Mochida Memorial Foundation for Medical & Pharmaceutical Research
2019 JSPS KAKENHI, Grant-in-Aid for Challenging Exploratory
Research
2019 Grants-in-Aid for Scientific Researcher(B)
2019 The Japan Geriatrics Society, Research Representative
2019 The Naito Foundation, Research Representative
2017 Elucidating and Controlling Mechanisms of Aging and Longevity, Japan Agency for Medical Research and Development (AMED)".
2017 Takeda Science Foundation, Research Representative
2017 Grant-in-Aid for Challenging Exploratory Research, Research Representative
2016 The Uehara Memorial Foundation, Research Representative
2016 Daiichi Sankyo Foundation of Life Science
2016 TERUMO FOUNDATION for LIFE SCIENCES and ARTS
2016 Kimura Memorial Heart Foundation, Research Representative
2016 Japan Diabetes Foundation, Research Representative
2016 The Bayer Scholarship for Cardiovascular Research, Research Representative
2016 Grants-in-Aid for Encouragement of Young Scientists (A) (JSPS KAKENHI Grant Number 16H06244) , Research Representative
2016 Inamori Foundation, Research Representative
2015 SENSHIN Medical Research Foundation, Research Representative
2015 Kanae Foundation Research Grant, Research Representative
2015 Grant for Basic Science Research Projects from The Sumitomo Foundation, Research Representative
2015 Banyu Foundation Research Grant, Research Representative
2015 Tsukada Grant for Niigata University Medical Research, Research Representative
2014 Japan Heart Foundation Research Grant, Research Representative
2014 The Uehara Memorial Foundation, Research Representative
2014 ONO Medical Research Foundation, Research Representative
2014 The Senri Life Science Foundation, Research Representative
2014 The Nakajima Foundation, Research Representative
2014 SENSHIN Medical Research Foundation, Research Representative
2014 Kowa Life Science Foundation, Research Representative
2014 SUZUKEN memorial foundation, Research Representative
2014 HOKUTO Corporation, Research Representative
2014 Grants-in-Aid for Young Scientists (Start-up) (KAKENHI) 26893080, Research
Representative
2014 Mochida Memorial Foundation for Medical & Pharmaceutical Research, Research
Representative
2013 Aging and geriatrics Novartis research foundation, exchanges overseas research grant,
Research Representative
2012 Manpei Suzuki Diabetes foundation, Research Representative
2012 Kanae Foundation for the Promotion of Medical Science, Research Representative
2011 Japan Heart Foundation/Novartis Research Award on Molecular and Cellular Cardiology,
Research Representative
2011 Kowa Life Science Foundation, Research Representative
2011 The Uehara Memorial Foundation, Research Representative
2011 Japan Society for the promotion of science, Grant-in-Aid for Young Scientists (B), Research
Representative
2011 Takeda Science Foundation, Research Representative
2010 Novartis research foundation, Research Representative
LECTURES
Instructor of case study for 3rd grade medical student, 1/10/2020
Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 1/6/2020
Instructor of case study for 3rd grade medical student, 12/14/2018
Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 12/14/2018
Adjunct instructor, Kumamoto University, 2018
Adjunct instructor, Nagoya University, 2017
Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 11/27/2017
Lecture for 2nd grade medical student, Physiological and pathological hypertrophy. 6/16/2017
Evaluator of Objective structured clinical examination (OSCE) for 4th grade medical student. 1/28/2017
Evaluator of simulated Objective structured clinical examination (OSCE) for 4th grade medical student. 1/17/2017
Instructor of Objective structured clinical examination (OSCE), clinical examination of vital check for 4th grade medical student. 12/19/2016
Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 9/29/2016
Instructor of case study for 3rd grade medical student, dyspnea and palpitation. 9/29/2016
Instructor of case study for 3rd grade medical student, chest pain. 10/16/2015
Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 10/15/2015
Instructor of case study for 3rd grade medical student, palpitation. 10/23/2014
Lecture for 3rd grade medical student, Anatomy, physiology and function of heart. 10/15/2014
ACADEMIC AND RESEARCH INTERESTS
Cardiovascular diseases, Heart failure, Obesity, Diabetes, Systemic insulin resistance, Chronic inflammation, Metabolism, Brown adipose tissue, Aging, Adipokines, Sympathetic nervous system
VOLUNTEER WORKS
Medical assistant team for Minamisanriku Miyagi, 2-6/April/2011
(Great East Japan Earthquake March/11th /2011)
