PUBLICATIONS

1. Yoshida Y*, Shimizu I*, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagmi H, Morishita R, Minamino T. Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity. Sci Rep 2019 Mar7; 9(1)3858 *Co-first author

2. Yokoyama M*, Shimizu I*, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol. 2019 Feb 18 *Co-first author

3. Wakasugi T*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Nakao M, Hoyano M Kashimura T, Nakamura K, Ito H, Nojiri T, Soga T, Minamino T. Role of smooth muscle cell p53 in pulmonary arterial hypertension. PLOS One. 2019 Feb 26, *Co-first author

4. Ikegami R*, Shimizu I*,**, Sato T*, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen N, Scheele C, Soga T, Minamino T**. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic dysfunction in obesity. *Co-first author, **Co-corresponding author Cell Rep. 24(11):2827-2837, 2018

5. Furuuchi R*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLOS One. 13(8):e0202051, 2018. *Co-first author

6. Kayamori H, Shimizu I, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T. Amlodipine inhibits vascular cell senescence and protects against atherogenesis through the mechanism independent of calcium channel blockade. Int Heart J. 2018 May 30;59(3):607-613

7. Katsuumi G*, Shimizu I*, Yoshida Y, Minamino T. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med 05 March 2018 https://doi.org/10.3389/fcvm.2018.00018. *Co-first author

8. Ikegami R*, Shimizu I*, Yoshida Y, Minamino T. Metabolomic analysis in heart failure. Circ J 2017 ;82(1):10-16 *Co-first author

9. Katsuumi G*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T. Catecholamine-induced cellular senescence in endothelium and bone-marrow cells promotes cardiac dysfunction in mice. Int Heart J. 2017 (in press) *Co-first author

10. Yoshida Y*, Shimizu I*,**, Minamino T**. Diabetes and adipocyte dysfunction. Diabetes and Aging-related Complications, 2017, 69-84 (Springer publication). *Co-first author, **Co-corresponding author

11. Suda M*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of Dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. *Co-first author PLOS One 2017 Aug 3; 12(8), e0182422.

12. Suda M*, Shimizu I*, Yoshida Y, Minamino T. Peripheral blood mononuclear cells for limb ischemia. Therapeutic Angiogenesis (Springer publication). p25-43, 2017, *Co-first author

13. Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yoshida Y, Tsuchida M, Iwama A, Hayano T and Tohru Minamino. Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. Oncotarget. 2017 May 23;8(21):34045-34056

14. Katsuumi G*, Shimizu I*,**, Yoshida Y, Minamino T**. Inflammation and regeneration., The pathological role of cardio-vascular aging in heart failure. (in press) *Co-first author, **Co-corresponding author

15. Shimizu I*, Minamino T*. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016 Jun 2;97:245-262 *Co-corresponding author

16. Maruyama S, Nakamura K, Papanicolaou N.K., Shimizu I, Sano S, Asaumi Y, van den Hoff M.J., Ouchi N, Recchia A.F., Walsh K. EMBO Mol Med (in press) Follistatin-like 1 is an endogenous regulator of cardiac fibroblast activation that protects the heart from post-infarct rupture.

17. Shimizu I, Yoshida Y, Minamino T. Hypertens Res (in press) A role for circadian clock in metabolic disease.

18. Nakamura K, Sano S, Fuster J, Kikuchi R, Shimizu I, Ohshima K, Katanasaka Y, Ouchi N, and Walsh K. J Biol Chem. 2015 Feb 5;291(6):2566-75Sfrp5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury.

19. Shimizu I, Yoshida Y, Minamino T. Diabetes. 2015 (Commentary) Dec;64(12):3984-6. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity.

20. Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I, Miki T, Kobayashi Y, and Minamino T. Aging and Mechanism of Disease. (Nature publishing Group), 2015 October, Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation.

21. Yoshida Y*, Shimizu I*, Minamino T. Inflammation and regeneration. 2015 September, The pathological role of adipose tissue aging in the progression of systemic insulin resistance. *Co-first author

22. Yoshida Y*, Shimizu I*, Katsuumi G*, Jiao S, Suda M, Hayashi Y, Minamino T. J Mol Cell Cardiol. 2015 June 85:183-198. p53-induced inflammation exacerbates cardiac dysfunction during pressure overload. *Co-first author

23. Shimizu I*, Yoshida Y, Minamino T*. Int Heart J. 2015 May 13;56(3):255-9. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders. *Co-corresponding author

24. Shimizu I*, Walsh K. Curr Obes Rep. 2015 June 4;(2):224-229. Whitening of brown fat and implications for weight management in obesity. *Corresponding author

25. Shimizu I, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab. 2014 Dec 2;20(6):967-977.

26. Kikuchi R, Nakamura K, Maclauchlan S, Ngo D, Shimizu I, Fuster J, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi T, Matsushita T, Murohara T, Gokce N, Bates D, Hamburg N, Walsh K. An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. Nat Med. 2014 Nov2.

27. Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T , Tojo K, Minamino T, Yoshimura M, Utsunomiya K. Diabetes. 2014 Sep3. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy

28. Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I, Minamino T. PLOS One. 2014; 9(6). Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway.

29. Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T. Cell reports. 2014 June12, 7, 1-13. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.

30. Shimizu I, Tamar A, Kikuchi R, Shimizu A, Papanicolaou K, Maclauchlan S, Maruyama S,Walsh K. J Clin Invest. 2014; Apr 4.Vascular rarefaction mediates whitening of brown fat in obesity.

31. Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. Cell Metab 2013; 18:4. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. (Featured article)

32. Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii Naoaki, Minamino T. PLOS One. 2013; 30;8(7) Haploinsufficiency of Akt1 prolongs the lifespan of mice.

33. Shimizu I, Walsh K. J Mol Cell Cardiol. 2013; 59C:176-178. Vascular remodeling mediated by Angptl2 produced from perivascular adipose tissue.

34. Shimizu I, Yoshida Y, Katsuno T, Minamino T. Microbes and Infection. 2013; 1:11-7. Adipose tissue inflammation in diabetes and heart failure.

35. Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi T. J Hepatol. (IF 10.401) 2012; 57, 837-843. P53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.

36. Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Cell. 2012; 149: 1298-313. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes.

37. Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I. Arterioscler Thromb Vasc Biol. 2012; 8: 1902-9.  Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway.

38. Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. Cell Metab. 2012; 15:51-64. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. (Featured article)

39. Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I. Hypertension. 2012; 59: 627-33. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.

40. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh G, Akazawa H, Shiojima I, Kahn C, Abel E, & Komuro I. J Clin Invest. 2010;120:1506-1514. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.

41. Moriya J, Minamino T, Tateno K, Okada S, Akiyoshi U. Shimizu I, Yokoyama M, Nojima A, Henderson CE, Okada M, Koga H, Komuro I. Circ Res. 2010; 106:391-8. Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis.

42. Shimizu I, Iguchi N, Watanabe H, Umemura J, Tobaru T, Asano R, Misu K, Nagayama M, Aikawa M Funabashi N, Komuro I, Sumiyoshi T. Int J Cardiol. 2010; 142:224-9. Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients.

43. Minamino T*, Orimo M*, Shimizu I*, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. Nat Med. 2009; 15:1082-7. A crucial role for adipose tissue p53 in the regulation of insulin resistance. *Co-first author

44. Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H and Komuro I. J. Exp. Med. 2009; 206:1565-74. Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure.

45. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. Nature. 2007; 446:444-8. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.

AWARDS

 

1.        Tsukano Y; Yujin Memorial Research Award for medical students, 2020

 

2.        Nakao M; Poster Award, N-Hybrid Conferenc 2019

 

3.        Katsuumi G; Ueda Heart Awards, 2019

 

4.        Suda M, New Investigator Travel Award, Basic Cardiovascular Sciences Scientific Sessions (BCVS) 2019, 2019, July 29-Aug1, Boston, USA.

 

5.        Hsiao YT; Poster Award, The 3rd JCS Council Forum on Basic CardioVascular Research 2019

 

6.        Katsuumi G; Poster Award, The 3rd JCS Council Forum on Basic CardioVascular Research 2019

 

7.        Katsuumi G; Basic Science Travel Grant, ESC Congress 2019, 2019 Aug 31-Sep 4, Paris, France.

 

8.        Wakasugi T; Clinical Research Award, JCS Kanto branch, 2018

 

9.        Yoshida Y; Kobe International Award, Japan Society for the Study of Obesity 2018

 

10.     Yoshida Y; Poster award, The 1st JCS Council Forum on Basic CardioVascular Research 2018

 

11.     Takashi Yamaguchi; Tobitate! (Leap for Tomorrow) Study Abroad Initiative, MEXT, 2018

 

12.     Takashi Yamaguchi; Yujin Memorial Research Award for medical students, 2018

 

13.     Suda M; Young Investigator Award, 11th Symposium on the pathophysiology of cancer, cardiovascular aging and metabolic syndrome, 2018

 

14.     Suda M; Young Investigator Award, 22nd CVEM, 2018

 

15.     Suda M; Young Investigator's Award, 26th Annual meeting of Japanese Vascular Biology and Medicine Organization, 208

 

16.     Katsuumi G; Society of Cerebral-Cardio-Vascular Anti-Aging 2017

 

17.     Hayashi Y; Best Moderated Poster Award, European Society of Cardiology (ESC) congress 2017, August 27

 

18.     Hayashi Y; Best presentation award; 17th Scientific Meeting of the Japanese Sciety of Anti-Aging Medicine, 2017

 

19.     Yoshida Y; Poster award, Society of Cerebral-Cardio-Vascular Anti-Aging 2017

 

20.     Yoshida Y; Young Investigator's Award, 25th Annual meeting of Japanese Vascular Biology and Medicine Organization, 2017

 

21.     Yoshida Y; Young Investigator's Award, The 21st Annual Scientific Meeting of the Japanese Heart Failure Society, Akita, Japan, 2017

 

22.     Shimizu I Takamine Jokichi Award, CVEM 2016

 

23.     Katsuumi G Poster Award4th Premium Hypertension Conference 2016/8/20

 

24.     Yoshida Y; The best Research Award, 10th Research Meeting on Hypertension and Coronary artery Disease, Research Foundation for Community Medicine. Tokyo, Japan. 2015/12/19

 

25.     Sato T; Yujin Memorial Research Award for medical students, 2016

 

26.     Jiao S; Niigata University Young Medical Investigation Award. 2015/10/28

 

27.     Yoshida Y; Travel Award for the ESC Congress 2015 in London, UK

 

28.     Suda M; Poster Award3rd Premium Hypertension Conference 2015/8/1

 

29.     Shimizu I; First Place, Young Investigator Competition of the 58th Annual Scientific Meeting. The Korean Society of Cardiology. Nov 28, 2014, Republic of Korea.

 

30.     Katsuumi G; Winner, Young Investigators Award, 18th Annual Meeting of the Society of Cardiovascular Endocrinology and Metabolism (CVEM) 2014, Yokohama, Japan

 

31.     Shimizu I; Dean’s award, Niigata University, 2014

 

32.     Katsuumi G; Travel Award for the 37th Annual Scientific Meeting of the Japanese Society of Hypertension 2014, Yokohama, Japan

 

33.     Yoshida Y; Travel Award for the ESC Congress 2014 in Barcelona, Spain

 

34.     Yoshida Y; The 7th Woman Researcher's Award, The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014, Tokyo, Japan

 

35.     Shimizu I; Best of the Day, Poster Award, XXI ISHR World Congress 2013, San Diego California, USA

 

36.     Shimizu I; Travel Award for the ISHR XXI World Congress 2013, San Diego California, USA

 

37.     Yoshida Y; Young Investigator Award, highest award, 2013, Society of Cerebral-Cardio-Vascular Anti-Aging, Osaka, Japan

 

38.     Yoshida Y; Poster Award, Miyazaki Science Camp 2013, Miyazaki, Japan

 

39.     Shimizu I; Winner, 2012 Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences, American Heart Association Scientific Sessions 2012, Los Angeles, USA

 


 

American Heart Association Scientific Sessions

2012, Los Angeles, USA