PUBLICATIONS

1.      Katsuumi G*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T. Catecholamine-induced cellular senescence in endothelium and bone-marrow cells promotes cardiac dysfunction in mice. Int Heart J. 2017 (in press) *Co-first author

2.      Suda M*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of Dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. *Co-first author PLOS One 2017 Aug 3; 12(8)

3.      Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yoshida Y, Tsuchida M, Iwama A, Hayano T and Tohru Minamino. Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. Oncotarget. 2017 May 23;8(21):34045-34056

4.      Katsuumi G*, Shimizu I*,**, Yoshida Y, Minamino T**. Inflammation and regeneration. 2016 Aug 36;16. The pathological role of vascular aging in cardio-metabolic disorder. *Co-first author, **Co-corresponding author

5.      Shimizu I*, Minamino T*. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016 Jun 2;97:245-262  *Co-corresponding author

6.      Maruyama S, Nakamura K, Papanicolaou N.K., Shimizu I, Sano S, Asaumi Y, van den Hoff M.J., Ouchi N, Recchia A.F., Walsh K. EMBO Mol Med. 2016 Aug 1; 8(8):949-66.  Follistatin-like 1 is an endogenous regulator of cardiac fibroblast activation that protects the heart from post-infarct rupture.

7.      Shimizu I, Yoshida Y, Minamino T. Hypertens Res 2016 Feb 18, A role for circadian clock in metabolic disease.  

8.      Nakamura K, Sano S, Fuster J, Kikuchi R, Shimizu I, Ohshima K, Katanasaka Y, Ouchi N, and Walsh K. J Biol Chem. 2015 Feb 5;291(6):2566-75 Sfrp5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury.

9.      Shimizu I, Yoshida Y, Minamino T. Diabetes. 2015 (Commentary) Dec;64(12):3984-6. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity.

10.   Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I, Miki T, Kobayashi Y, and Minamino T. Aging and Mechanism of Disease. (Nature publishing Group), 2015 October, Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation.

11.   Yoshida Y*, Shimizu I*, Minamino T. Inflammation and regeneration. 2015 September, The pathological role of adipose tissue aging in the progression of systemic insulin resistance. *Co-first author

12.   Yoshida Y*, Shimizu I*, Katsuumi G*, Jiao S, Suda M, Hayashi Y, Minamino T. J Mol Cell Cardiol. 2015 June 85:183-198. p53-induced inflammation exacerbates cardiac dysfunction during pressure overload. *Co-first author

13.   Shimizu I*, Yoshida Y, Minamino T*. Int Heart J. 2015 May 13;56(3):255-9. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders. *Co-corresponding author

14.   Shimizu I*, Walsh K. Curr Obes Rep. 2015 June 4;(2):224-229. Whitening of brown fat and implications for weight management in obesity. *Corresponding author

15.   Shimizu I, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab. 2014 Dec 2;20(6):967-977.

16.   Kikuchi R, Nakamura K, Maclauchlan S, Ngo D, Shimizu I, Fuster J, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi T, Matsushita T, Murohara T, Gokce N, Bates D, Hamburg N, Walsh K. Nat Med. 2014 Nov2 An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease.

17.   Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T , Tojo K, Minamino T, Yoshimura M, Utsunomiya K. Diabetes. 2014 Sep3. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy

18.   Ito TK, Yokoyama M, Yoshida Y, Nojima A, Kassai H, Oishi K, Okada S, Kinoshita D, Kobayashi Y, Fruttiger M, Aiba A, Minamino T. A Crucial Role for CDC42 in Senescence-Associated Inflammation and Atherosclerosis. PLoS One. 2014; 9(7):e102186.

19.   Yoshida Y*, Hayashi Y*, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I, Minamino T. PLOS One. 2014; 9(6). Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway.

20.   Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T. Cell reports. 2014 June12, 7, 1-13. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.

21.   Shimizu I, Tamar A, Kikuchi R, Shimizu A, Papanicolaou K, Maclauchlan S, Maruyama S,Walsh K. J Clin Invest. 2014; Apr 4. Vascular rarefaction mediates whitening of brown fat in obesity.

22.   Shimizu I*, Yoshida Y*, Moriya J*, Nojima A, Uemura A, Kobayashi Y, Minamino T. Cell Metab 2013; 18:4. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. *Co-first author (Featured article)

23.   Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii Naoaki, Minamino T. PLOS One. 2013; 30;8(7). Haploinsufficiency of Akt1 prolongs the lifespan of mice.

24.   Shimizu I, Walsh K. J Mol Cell Cardiol. 2013; 59C:176-178. Vascular remodeling mediated by Angptl2 produced from perivascular adipose tissue.

25.   Shimizu I, Yoshida Y, Katsuno T, Minamino T. Microbes and Infection. 2013; 1:11-7. Adipose tissue inflammation in diabetes and heart failure.

26.   Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Cell. 2012; 149: 1298-313. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes.

27.   Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I. Arterioscler Thromb Vasc Biol. 2012; 8: 1902-9.  Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway.

28.   Shimizu I*, Yoshida Y*, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. Cell Metab. 2012; 15:51-64. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. *Co-first author (Featured article)

29.   Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I. Hypertension. 2012; 59: 627-33. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.

30.   Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh G, Akazawa H, Shiojima I, Kahn C, Abel E, & Komuro I. J Clin Invest. 2010;120:1506-1514. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.

31.   Moriya J, Minamino T, Tateno K, Okada S, Akiyoshi U. Shimizu I, Yokoyama M, Nojima A, Henderson CE, Okada M, Koga H, Komuro I. Circ Res. 2010; 106:391-8. Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis.

32.   Minamino T*, Orimo M*, Shimizu I*, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. Nat Med. 2009; 15:1082-7. A crucial role for adipose tissue p53 in the regulation of insulin resistance. *Co-first author

33.   Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H and Komuro I. J. Exp. Med. 2009; 206:1565-74. Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure.

34.   Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. Nature. 2007; 446:444-8. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.

 

BOOKS

1.        Suda M*, Shimizu I*, Yoshida Y, Minamino T. Peripheral blood mononuclear cells for limb ischemia. Therapeutic Angiogenesis (Springer publication). p25-43, 2017, *Co-first author

2.        Yoshida Y*, Shimizu I*,**, Minamino T**. Diabetes and adipocyte dysfunction. Diabetes and Aging-related Complications (Springer publication). (in press). *Co-first author, **Co-corresponding author

AWARDS

1.        Yoshida Y. Winner, Young Investigator's Award, The 21st Annual Scientific Meeting of the Japanese Heart Failure Society, Akita, Japan

2.        Hayashi Y, Niigata University Young Medical Investigation Award, 10/6/2017, Niigata, Japan

3.        Hayashi Y, Best Moderated Poster Award, European Society of Cardiology congress 2017, August 27, Barcelona, Spain.

4.        Hayashi Y, Best presenter award. 17th Scientific Meeting of the Japanese Sciety of Anti-Aging Medicine, 6/2-4/2017, Tokyo, Japan

5.        Ikegami R, Winner, Young Investigator's Award, Society of Cerebral-Cardio-Vascular Anti-Aging, 12/18/2016, Tokyo, Japan.

6.        Nagasawa A, Poster award, Society of Cerebral-Cardio-Vascular Anti-Aging, 12/17/2016, Tokyo, Japan

7.        Shimizu I, Jokichi Takamine Memorial Award, CVEM (The Society of Cardiovascular Endocrinology and Metabolism), 12/16/2016.

8.        Katsuumi G Poster Award4th Premium Hypertension Conference 2016/8/20

9.        Yoshida Y; The best Research Award, 10th Research Meeting on Hypertension and Coronary artery Disease, Research Foundation for Community Medicine. Tokyo, Japan. 2015/12/19

10.     Jiao S; Niigata University Young Medical Investigation Award. 2015/10/28

11.     Yoshida Y; Travel Award for the ESC Congress 2015 in London, UK

12.     Suda M; Poster Award3rd Premium Hypertension Conference 2015/8/1

13.     Shimizu I; First Place, Young Investigator Competition of the 58th Annual Scientific Meeting. The Korean Society of Cardiology. Nov 28, 2014, Republic of Korea.

14.     Katsuumi G; Winner, Young Investigators Award, 18th Annual Meeting of the Society of Cardiovascular Endocrinology and Metabolism (CVEM) 2014, Yokohama, Japan

15.     Shimizu I; Dean’s award, Niigata University, 2014

16.     Katsuumi G; Travel Award for the 37th Annual Scientific Meeting of the Japanese Society of Hypertension 2014, Yokohama, Japan

17.     Yoshida Y; Travel Award for the ESC Congress 2014 in Barcelona, Spain

18.     Yoshida Y; The 7th Woman Researcher's Award, The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014, Tokyo, Japan

19.     Shimizu I; Best of the Day, Poster Award, XXI ISHR World Congress 2013, San Diego California, USA

20.     Shimizu I; Travel Award for the ISHR XXI World Congress 2013, San Diego California, USA

21.     Yoshida Y; Young Investigator Award, highest award, 2013, Society of Cerebral-Cardio-Vascular Anti-Aging, Osaka, Japan

22.     Yoshida Y; Poster Award, Miyazaki Science Camp 2013, Miyazaki, Japan

23.     Shimizu I; Winner, 2012 Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences, American Heart Association Scientific Sessions 2012, Los Angeles, USA

 

American Heart Association Scientific Sessions

2012, Los Angeles, USA